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首页> 外文期刊>Cytokine >Analysis of interleukins 6, 8, 10 and 17 in the lungs of premature neonates with bronchopulmonary dysplasia
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Analysis of interleukins 6, 8, 10 and 17 in the lungs of premature neonates with bronchopulmonary dysplasia

机译：用支气管扩张发育不良的早产新生儿肺中白细胞介素6,8,10和17分析

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摘要

Bronchopulmonary dysplasia (BPD) is an abnormality that occurs in premature neonate lung development. The pathophysiology is uncertain, but the inflammatory response to lung injury may be the responsible pathway. The objective of this study is to evaluate the role of interleukins 6, 8, 10, and 17 through the anatomopathological and immunohistochemical study of the lungs of premature neonates with BPD. Thirty-two cases of neonatal autopsies from the Pathology Department of the Clinics Hospital of the Universidade Federal do Parana, who presented between 1991 and 2005 were selected. The sample included neonates less than 34 weeks of gestational age who underwent oxygen therapy and had pulmonary formalin-fixed paraffin-embedded (FFPE) samples. Pulmonary specimens were later classified into three groups according to histopathological and morphometric changes (classic BPD, new BPD, and without BPD) and subjected to immunohistochemical analysis. The antibodies selected for the study were anti-IL-6, anti-IL-8, anti-IL-10, and anti-IL-17A monoclonal antibodies. IL-6, IL-8, and IL-10 showed no significant differences in tissue expression among the groups. IL-17A had higher tissue immunoreactivity in the group without BPD compared with the classic BPD group (1686 vs. 866 mu m(2), p = 0.029). This study showed that the involvement of interleukins 6, 8, and 10 might not be significantly different between the two types of BPD. We speculated that IL-17A could be a protective factor in this disease.
机译：支气管扩漏（BPD）是一种异常发生在早产的新生儿肺部发育。病理生理学是不确定的，但对肺损伤的炎症反应可能是负责任的途径。本研究的目的是评估白细胞介素6,8,10和17通过对BPD过早新生儿肺部的解剖病理学和免疫组织化学研究的作用。从1991年至2005年间提供的普遍媒体医院病理署的32例新生儿尸检案件被选中。该样品包括少于34周的胎儿妊娠期患者的新生儿，他接受氧气治疗并具有肺福尔马林固定的石蜡包埋（FFPE）样品。根据组织病理学和形态学变化（经典BPD，新BPD，没有BPD）并进行免疫组化分析，肺样本后将被归类为三组。为该研究选择的抗体是抗IL-6，抗IL-8，抗IL-10和抗IL-17A单克隆抗体。 IL-6，IL-8和IL-10显示群体中的组织表达没有显着差异。与经典的BPD组（1686 vs.866mu m（2），p = 0.029）相比，IL-17A在没有BPD的组中具有更高的组织免疫反应性。该研究表明，白细胞介素6,8和10之间的参与在两种类型的BPD之间可能不会显着差异。我们推测IL-17A可能是这种疾病的保护因素。

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