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首页> 外文期刊>Cytokine >The Dectin-2 family of C-type lectins in immunity and homeostasis.
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The Dectin-2 family of C-type lectins in immunity and homeostasis.

机译：免疫和稳态中的Dectin-2 C型凝集素。

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摘要

C-type lectins are a diverse family of proteins which recognize a wide range of ligands. This review focuses on the Dectin-2 family of C-type lectins that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes are clustered in the telomeric region of the NK-gene cluster on mouse chromosome 6 and human chromosome 12. These type II receptors are expressed on myeloid and non-myeloid cells and contain a single extracellular carbohydrate recognition domain and have diverse functions in both immunity and homeostasis. DCIR is the only member of the family which contains a cytoplasmic signalling motif and has been shown to act as an inhibitory receptor, while BDCA-2, Dectin-2, DCAR and Mincle all associate with FcRgamma chain to induce cellular activation, including phagocytosis and cytokine production. Dectin-2 and Mincle have been shown to act as pattern recognition receptors for fungi, while DCIR acts as an attachment factor for HIV. In addition to pathogen recognition, DCIR has been shown to be pivotal in preventing autoimmune disease by controlling dendritic cell proliferation, whereas Mincle recognizes a nuclear protein released by necrotic cells. Here we review each of these receptors in detail describing their expression, ligand recognition, signalling and known physiological functions.
机译：C型凝集素是一种多样的蛋白质，识别各种配体。本综述重点介绍了包括Dectin-2，BDCA-2，DCIR，DCAR，CLECSF8和MINCE在小鼠染色体6的NK-基因簇的端粒区域中聚集的Dectin-2，BDCA-2，DCIR，DCAR，CLECSF8和MOCCE的C型凝集素。人染色体12.这些II型受体在髓样和非骨髓细胞上表达并含有单一细胞外碳水化合物识别结构域，并且在免疫和稳态中具有不同的功能。 DCIR是含有细胞质信号传导基序的家族的唯一成员，并且已被证明用作抑制受体，而BDCA-2，Dectin-2，DCar和Mincle则所有与Fcrgamma链相关联，以诱导细胞活化，包括吞噬作用，包括吞噬作用细胞因子生产。已显示Dectin-2和Mincle作为真菌的模式识别受体，而DCIR充当HIV的附着因素。除了病原体识别之外，DCIR已经显示在通过控制树突细胞增殖来预防自身免疫性疾病的枢转，而MINE识别由坏死细胞释放的核蛋白质。在这里，我们详细审查了这些受体中的每一个，描述了它们的表达，配体识别，信号传导和已知的生理功能。

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  • 来源
    《Cytokine》 |2009年第2期|共8页
  • 作者

    Graham LM; Brown GD;

  • 作者单位

    Wernher &

    Beit Building South Institute of Infectious Disease and Molecular Medicine University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
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