...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Infection and metabolism - Streptococcus pneumoniae metabolism facing the host environment
【24h】

Infection and metabolism - Streptococcus pneumoniae metabolism facing the host environment

机译：感染和新陈代谢 - 肺炎链球菌代谢面对宿主环境

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Streptococcus pneumoniae, a Gram-positive bacterium, can cause a broad range of severe diseases including pneumonia, septicemia and meningitis. The pneumococcal pathophysiology is highly dependent on host nutrients such as purines, pyrimidines, amino acids and carbon sources. The study of S. pneumoniae metabolism is essential for understanding the adaption strategies that are required to deal with the host environment during infection and to identify possible new drug targets. By using a combination of high analytical techniques, such as nuclear magnetic resonance (NMR), liquid chromatography (LC) and/or gas chromatography (GC) coupled with mass spectroscopy (MS) the metabolism of S. pneumoniae can be precisely investigated. This review summarizes the metabolism and major virulence factors of S. pneumoniae within the context of infection. Furthermore, it addresses the antibiotic resistance and its influence on metabolism as well as new antimicrobial substances for the treatment of S. pneumoniae.
机译：肺炎链球菌，革兰氏阳性细菌，可引起广泛的严重疾病，包括肺炎，败血症和脑膜炎。肺炎球菌病理生理学高度依赖于宿主营养素，如嘌呤，嘧啶，氨基酸和碳源。肺炎肺炎代谢的研究对于了解在感染期间处理宿主环境所需的适应策略至关重要，并确定可能的新药物目标。通过使用高分析技术的组合，例如核磁共振（NMR），液相色谱（LC）和/或气相色谱（GC）与质谱（MS）偶联（MS）可以精确地研究S.肺炎的代谢。本综述总结了在感染范围内S.肺炎的代谢和主要毒力因子。此外，它解决了抗生素抗性及其对代谢的影响以及治疗S.肺炎的新抗微生物物质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号