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首页> 外文期刊>Cytokine >Concentration of vascular endothelial growth factor in patients with acute coronary syndrome
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Concentration of vascular endothelial growth factor in patients with acute coronary syndrome

机译：急性冠状动脉综合征患者血管内皮生长因子的浓度

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摘要

Vascular endothelial growth factor (VEGF) is a regulator of vascular formation in physiological and pathological conditions. The aim of our study was to evaluate the value of VEGF as a surrogate marker of myocardial injury in acute ischemic conditions. Materials and methods: In 104 consecutive patients with acute coronary syndrome (ACS) with and without ST segment elevation (STEMI and NSTEMI) the plasma and serum human VEGF (hVEGF) concentration was measured two times i.e. immediately after admission due to ACS and 24. h later. According to ECG findings and coronary angiography results, patients were divided into three groups. Group A represented major myocardial injury due to ST-segment elevation in precordial leads and/or in I and aVL leads and with left anterior descending (LAD) artery responsible for STEMI symptoms or additionally with significant atherosclerotic lesions (lumen vessel narrowed >50%) in other than LAD coronary arteries. Group B (medium myocardial injury) consisted of patients with ST-segment elevation in II, III and aVF leads and/or ST-segment depression in V2-V3 leads with one-vessel disease and the culprit artery was not LAD. Group C included patients with changes in ECG other than ST-segment elevation independently of the site of atherosclerotic lesions in coronary arteries. Results: In all 104 patients with ACS the highest values of serum hVEGF were observed in second measurement (357.9 ?? 346 pg/ml, p< 0.01). Although in the first measurement, plasma and serum hVEGF concentration did not differentiate groups, the difference between deltas for serum hVEGF was observed (p< 0.05). Increased number of neutrophils in the first measurement increased the OR of the high serum hVEGF concentration in the first measurement (OR = 1.155; 95%CI: 1.011; 1.32) (p< 0.05). The number of neutrophils in the second measurement also revealed significant relationship with high serum hVEGF in the first assessment (OR = 1.318, 95%CI: 1.097; 1.583) (p< 0.01). Increased values of triglycerides (exceeding the upper limit) were connected with decreased OR of high serum hVEGF concentrations in the first measurement (OR = 0.152, 95%CI: 0.033; 0.695, p< 0.05). Conclusions: In acute coronary syndrome, serum VEGF concentrations are elevated and can serve as a surrogate marker of myocardial injury. The elevated number of neutrophils increases odds ratio of high VEGF concentrations in ACS. In patients with high concentrations of triglycerides, odds ratio of low level of hVEGF is expected. ? 2012 Elsevier Ltd.
机译：血管内皮生长因子（VEGF）是生理和病理条件下血管形成的调节因子。我们研究的目的是评估VEGF作为急性缺血条件中心肌损伤的替代标志物的价值。材料和方法：在104例连续冠状动脉综合征（ACS）患者中，没有ST段抬高（STEMI和NSTEMI），等离子体和血清人VEGF（HVEGF）浓度是两次，即在入院后立即引起AC和24。 H后来。根据心电图调查结果和冠状动脉造影结果，患者分为三组。组A代表性的主要心肌损伤，由于心脏前缘和/或IAVL引线和左前期下降（LAD）动脉，负责STEMI症状或另外具有显着的动脉粥样硬化病变（腔血管缩小> 50％）除了LAD冠状动脉。 B组（中型心肌损伤）由II，III和AVF引线和/或ST段抑郁患者组成，V2-V3中的患者和/或ST段抑郁患有一艘船疾病，罪魁祸首不是LAD。 C组包括患者在冠状动脉中动脉粥样硬化部位的ST段升高之外的ECG以外的变化。结果：在所有104例ACS患者中，在第二次测量中观察到血清HVEGF的最高值（357.9 ?? 346 pg / ml，P <0.01）。虽然在第一次测量中，等离子体和血清HVEGF浓度没有区分基团，但观察到血清HVEGF的δ之间的差异（P <0.05）。第一次测量中的中性粒细胞数量增加增加了第一次测量中的高血清HVEGF浓度（或= 1.155; 95％CI：1.011; 1.32）（P <0.05）。第二次测量中的中性粒细胞的数量也揭示了第一种评估中与高血清HVEGF的显着关系（或= 1.318,95％CI：1.097; 1.583）（P <0.01）。在第一次测量中，甘油三酯（超过上限）的增加的甘油三酯（超过上限）的值（或= 0.152,95％CI：0.033; 0.695，P <0.05）。结论：在急性冠状动脉综合征中，血清VEGF浓度升高，可用作心肌损伤的替代标志物。升高的中性粒细胞数量增加了ACS中高VEGF浓度的差距。在高浓度甘油三酯的患者中，预期低水平的HVEGF的差距。还2012年elestvier有限公司

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  • 来源
    《Cytokine》 |2013年第2期|共6页
  • 作者

    KonopkaA.; JanasJ.; PiotrowskiW.; StepińskaJ.;

  • 作者单位

    Institute of Cardiology Intensive Cardiac Therapy Clinic Alpejska 42 04-628 Warsaw Poland;

    Institute of Cardiology Intensive Cardiac Therapy Clinic Alpejska 42 04-628 Warsaw Poland;

    Institute of Cardiology Intensive Cardiac Therapy Clinic Alpejska 42 04-628 Warsaw Poland;

    Institute of Cardiology Intensive Cardiac Therapy Clinic Alpejska 42 04-628 Warsaw Poland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Acute coronary syndrome; Biomarkers; NSTEMI; STEMI; VEGF;

    机译：急性冠状动脉综合征;生物标志物;nstemi;Stemi;VEGF;

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