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The IL-12 cytokine family in cardiovascular diseases

机译：IL-12细胞因子家庭在心血管疾病中

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摘要

Cytokines of the Interleukin (IL)-12 family, consisting of IL-12, IL-23, IL-27 and IL-35, are important regulators in (chronic) inflammatory disorders such as rheumatoid arthritis and multiple sclerosis, but also in cardiovascular diseases. Cytokines of the IL-12 family consist of two subunits and are known for their regulatory functions in the immunologic response, more specifically in the regulation and differentiation of T-helper (Th) cells such as Th1 and Th17 cells. Binding of these cytokines to its specific heterodimeric receptor results in the activation of the JAK-STAT signaling. Despite similarities in structure, the members of the IL-12 family have diverse, both pro and anti-inflammatory, effects and functions. Because of the pro-inflammatory effects of IL-12 cytokine family members on immune responses, the IL-12 cytokines have been implicated in the development and progression of cardiovascular diseases such as atherosclerosis, but also in acute cardiovascular syndromes such as myocardial infarction and stroke. For example, patients suffering from cardiovascular disease display increased blood levels of IL-12, IL-23 and IL-27, while decreased IL-35 levels have been linked to a lower cardiovascular risk. In this review, we aim to highlight the current understandings of the IL-12 cytokine family and its specific family members to cardiovascular diseases, including both clinical and experimental studies. We will also discuss the potential of these cytokines as a biomarker in acute cardiovascular syndromes.
机译：由IL-12，IL-23，IL-27和IL-35组成的白细胞介素（IL）-12系列的细胞因子是（慢性）炎症性疾病（如类风湿性关节炎和多发性硬化症）的重要调节因子，也是心血管疾病。 IL-12家族的细胞因子由两个亚基组成，以其在免疫应答中的调节功能而闻名，更具体地，在T-Helper（Th）细胞如Th1和Th17细胞的调节和分化中。这些细胞因子与其特定的异二聚体受体的结合导致jak-stat信号传导的激活。尽管结构中的相似之处，IL-12家族的成员具有多种多样的，既具有多样化，又抗炎，效果和功能。由于IL-12细胞因子家庭成员对免疫反应的炎症作用，IL-12细胞因子涉及动脉粥样硬化等心血管疾病的开发和进展，也是急性心血管综合征，如心肌梗死和中风。例如，患有心血管疾病的患者显示IL-12，IL-23和IL-27的增加血液水平，同时降低IL-35水平与较低的心血管风险有关。在这篇综述中，我们的目标是突出IL-12细胞因子家族及其特定家庭成员对心血管疾病的当前谅解，包括临床和实验研究。我们还将在急性心血管综合征中讨论这些细胞因子作为生物标志物的潜力。

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