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Cytokine receptor splice variants in hematologic diseases

机译：细胞因子受体均衡血液疾病中的变体

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Cytokine and cytokine receptors are important regulators of hematopoiesis. Hematopoietic stem cells (HSCs) and progenitors differentiate into the myeloid or lymphoid lineage in response to specific cytokines. Cell-type specific receptors are expressed on committed progenitors that bind to other late-acting cytokines that are involved in terminal differentiation of hematopoietic cells. In normal hematopoiesis, these receptors undergo alternative splicing and are developmentally regulated. Splicing changes can significantly affect the structure and function of the receptors resulting in alterations of either the extracellular ligand binding domain or the cytoplasmic signaling domain responsible for cellular growth and differentiation. Most alternatively spliced isoforms generally lose the ability to promote differentiation. Evidently, overexpression of naturally occurring cytokine receptor alternate isoforms are observed in multiple myeloid diseases such as myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and polycythemia vera (PV). The purpose of this review is to introduce the various isoforms of key cytokine receptors that play a crucial role in myeloid development and their potential role in myeloid diseases.
机译：细胞因子和细胞因子受体是血缺陷的重要调节因子。造血干细胞（HSC）和祖细胞与特异性细胞因子的响应分化为骨髓或淋巴结谱系。细胞型特异性受体在引发的祖细胞上表达，其与参与造血细胞末端分化的其他晚期作用细胞因子结合。在正常血液缺血中，这些受体接受替代剪接，并在发育中调节。剪接变化可以显着影响受体的结构和功能，导致细胞外配体结合结构域或负责细胞生长和分化的细胞质信号域的改变。最替代的剪接同种型通常失去促进分化的能力。显然，在多个骨髓疾病（如骨髓增生综合征（MDS），急性髓性白血病（AML）等多个骨髓疾病中观察到天然存在的细胞因子受体交替同种型的过表达观察到过表达。本综述的目的是介绍关键细胞因子受体的各种同种型，这些受体在骨髓发育中发挥至关重要的作用及其在骨髓疾病中的潜在作用。

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