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Chemokines in pregnant women with sickle cell disease

机译:在孕妇的趋化因子有镰状细胞疾病的妇女

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Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups. There were no differences in MCP-1 level among the groups, but IL-8 and MIG were likely related with disease activity. In addition, levels of IP-10 were higher in pregnant women with sickle cell disease and, interestingly, RANTES levels were higher in normal pregnancy when compared to pregnancy in sickle cell disease. More studies should be encouraged to fully elucidate chemokine activity during pregnancy in sickle cell disease.
机译:由于与疾病有关的不良结果,镰状细胞病的妊娠是一个问题。 研究趋化因子在镰状细胞疾病中的作用,但研究妊娠中疾病的研究是稀缺的。 我们的数据显示与对照组相比,患有镰状细胞疾病的孕妇的趋化因素谱。 组中MCP-1水平没有差异,但IL-8和MIG可能与疾病活动有关。 此外,患有镰状细胞疾病的孕妇的IP-10水平较高,有趣的是,与镰刀细胞疾病的妊娠相比,正常妊娠咆哮水平较高。 应鼓励更多的研究在镰状细胞疾病怀孕期间完全阐明趋化因子活动。

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