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首页> 外文期刊>Acta oncologica. >Health-related quality of life and anxiety and depression in patients diagnosed with cholangiocarcinoma: a prospective cohort study
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Health-related quality of life and anxiety and depression in patients diagnosed with cholangiocarcinoma: a prospective cohort study

机译：患有胆管癌患者的患者的健康有关的生活质量和抑郁症：一项潜在的队列研究

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Background: Cholangiocarcinoma (CCA) is a rare cancer associated with a poor prognosis. Psychosocial challenges may negatively affect daily functioning and health-related quality of life (HRQOL). The primary aim was to evaluate HRQOL, and to assess anxiety and depression in these patients.Material and methods: From 93 eligible patients diagnosed with CCA, 76 were included in a prospective cohort over a period of 15 months. Patients answered the European Organization for Research and Treatment of Cancer QLQ C30 (EORTC QLQ C30) and Hospital Anxiety and Depression Scale (HADS) questionnaires at baseline, one, three and six months after initial treatment; defined as radical operation, explorative laparotomy, chemotherapy or drainage of the bile ducts. Scores were compared between the radically operated patients (n=25) and palliative patients (n=51; 12 of these had explorative laparotomy), using repeated measures ANOVA and unpaired ANOVA.Results: The groups were similar in demographic characteristics, except for fewer radically operated men (p=0.015). There was no significant change over time in HRQOL in total or between groups. At baseline nausea and vomiting scores were higher in the palliative group (p=0.035), and at one month follow-up, the radical group had higher pain scores (p=0.009). The majority reported normal/mild anxiety and depression throughout the study; there were no differences between the groups.Conclusions: It was not possible to measure any differences between the groups, regarding HRQOL, anxiety or depression, despite the fact that one of the groups had the prospect of total cure. In clinical settings, observed mean changes in HRQOL scores are generally small; probably due to psychological adaptation by patients to changing health status over time.
机译：背景：胆管癌（CCA）是一种罕见的癌症，其预后不良。心理社会挑战可能会对日常运作和健康有关的生活质量（HRQOL）产生负面影响。主要目的是评估HRQOL，并评估这些患者中的焦虑和抑郁..80：从93例诊断为CCA的符合条件的患者，76名在15个月内包含在预期队列中。患者回答欧洲研究和治疗癌症QLQ C30（EORTC QLQ C30）和医院焦虑和抑郁规模（曾）问卷在基线，初步治疗后的三个月和六个月内的研究和抑郁症组织;定义为自由基操作，探索性剖腹手术，化疗或胆管的排水。在从根本上操作的患者（n = 25）和姑息患者（n = 51; 12中有探索性剖腹产术）之间进行比较分数，使用反复措施ANOVA和UNAPARED ANOVA.RESULTS：除了更少的人口特征外，组在人口特征中类似自然的男性（P = 0.015）。在HRQOL中没有显着变化，总数或团体之间。在基线恶心和呕吐分数较高的姑息组（P = 0.035），并且在一个月的随访时，激进的疼痛分数较高（p = 0.009）。大多数人在整个研究中报告了正常/轻度焦虑和抑郁症;群体之间没有差异。结论：尽管其中一群人具有全治治愈的前景，但仍然无法衡量群体之间的群体之间的任何差异。在临床环境中，观察到HRQOL分数的平均变化通常很小;可能是由于患者的心理适应随着时间的推移而改变健康状况。

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