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首页> 外文期刊>Acta oncologica. >FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach
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FDG-PET reproducibility in tumor-bearing mice: comparing a traditional SUV approach with a tumor-to-brain tissue ratio approach

机译：携带肿瘤小鼠的FDG-PET再现性：与肿瘤对脑组织比率比较的传统SUV方法

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Background: Current [F-18]-fluorodeoxyglucose positron emission tomography (FDG-PET) procedures in tumor-bearing mice typically includes fasting, anesthesia, and standardized uptake value (SUV)-based quantification. Such procedures may be inappropriate for prolonged multiscan experiments. We hypothesize that normalization of tumor FDG retention relative to a suitable reference tissue may improve accuracy as this method may be less susceptible to uncontrollable day-to-day changes in blood glucose levels, physical activity, or unnoticed imperfect tail vein injections.Material and methods: Fed non-anesthetized tumor-bearing mice were administered FDG intravenously (i.v.) or intraperitoneally (i.p.) and PET scanned on consecutive days using a Mediso nanoScan PET/magnetic resonance imaging (MRI). Reproducibility of various PET-deduced measures of tumor FDG retention, including normalization to FDG signal in reference organs and a conventional SUV approach, was evaluated.Results: Day-to-day variability in i.v. injected mice was lower when tumor FDG retention was normalized to brain signal (T/B), compared to normalization to other tissues or when using SUV-based normalization. Assessment of tissue radioactivity in dissected tissues confirmed the validity of PET-derived T/B ratios. Mean T/B and SUV values were similar in i.v. and i.p. administered animals, but SUV normalization was more robust in the i.p. group than in the i.v. group.Conclusions: Multimodality scanners allow tissue delineation and normalization of tumor FDG uptake relative to reference tissues. Normalization to brain, but not liver or kidney, improved scan reproducibility considerably and was superior to traditional SUV quantification in i.v. tracer-injected animals. Day-to-day variability in SUV's was lower in i.p. than in i.v. injected animals, and i.p. injections may therefore be a valuable alternative in prolonged rodent studies, where repeated vein injections are undesirable.
机译：背景：肿瘤小鼠中的电流[F-18] - 氟二氧氧鎓葡萄糖（FDG-PET）程序通常包括禁食，麻醉和标准化摄取值（SUV）的量化。这些程序对于长期的多股票实验可能是不合适的。我们假设肿瘤FDG保留相对于合适的参考组织的归一化可以提高精度，因为该方法可能不易受到血糖水平，身体活动或未染色的尾静脉注射的无法控制的日常变化。材料和方法：使用Mediso NanoScan PET /磁共振成像（MRI），静脉内（IV）或腹膜内（IP）或腹膜内（IP）和PET扫描喂食非麻醉瘤小鼠。评估各种宠物DDG保留措施的肿瘤FDG潴留的措施的再现性，包括参考器官中的FDG信号和传统的SUV方法。结果：I.V中的日常变异性。当肿瘤FDG保留归一化为脑信号（T / B）时，注射小鼠较低，与其他组织的归一化或使用基于SUV的标准化相比。解剖组织中组织放射性的评估证实了PET衍生的T / B比的有效性。 I.v的平均t / b和SUV值相似。和i.p.施用的动物，但SUV归一化在I.P中更稳健。小组比I.v. Group.conclusions：多模扫描仪允许组织描绘和肿瘤FDG摄取相对于参考组织的归一化。对脑的归一化，但不是肝脏或肾脏，显着提高了扫描再现性，并且优于I.V中的传统SUV定量。跟踪动物。 SUV的日常变异在I.P中较低。比I.v。注射动物和i.p.因此，注射可能是延长啮齿动物研究中的有价值的替代品，其中重复的静脉注射是不希望的。

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