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首页> 外文期刊>Acta oncologica. >Histological grade provides significant prognostic information in addition to breast cancer subtypes defined according to St Gallen 2013
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Histological grade provides significant prognostic information in addition to breast cancer subtypes defined according to St Gallen 2013

机译：组织学等级除了根据ST Gallen 2013定义的乳腺癌亚型外，还提供了显着的预后信息

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Background: The St Gallen surrogate definition of the intrinsic subtypes of breast cancer consist of five subgroups based on estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor type 2 (HER2), and Ki-67. PgR and Ki-67 are used for discriminating between the 'Luminal A-like' and 'Luminal B-like (HER2-negative)' subtypes. Histological grade (G) has prognostic value in breast cancer; however, its relationship to the St Gallen subtypes is not clear. Based on a previous pilot study, we hypothesized that G could be a primary discriminator for ER-positive/HER2-nega-tive breast cancers that were G1 or G3, whereas Ki-67 and PgR could provide additional prognostic information specifically for patients with G2 tumors. To test this hypothesis, a larger patient cohort was examined.
机译：背景：乳腺癌内在亚型的St Gallen替代定义由基于雌激素受体（ER），孕酮受体（PGR），人表皮生长因子受体类型2（HER2）和Ki-67的五个亚组组成。 PGR和KI-67用于区分“腔A型”和'腔B样（HER2-阴性）'亚型之间的区分。 组织学等级（g）具有乳腺癌的预后价值; 然而，它与St Gallen亚型的关系尚不清楚。 基于以前的试点研究，我们假设G可以是G1或G3的ER-阳性/ HER2-Nega-Ciet乳腺癌的主要鉴别器，而Ki-67和PGR可以专门为G2患者提供额外的预后信息 肿瘤。 为了测试这一假设，检查了更大的患者队列。

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