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Interplay between endoplasmic reticulum membrane contacts and actomyosin cytoskeleton

机译:内质网膜接触和肌动素细胞骨架之间的相互作用

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摘要

Eukaryotic membrane-bound organelles, exhibiting distinctive morphologies, dynamics and functions, are interconnected at membrane contact sites (MCSs) through numerous tethering machineries. MCSs are required for many fundamental cellular processes, such as non-vesicular lipid transfer, calcium transport and organelle homeostasis. Actin cytoskeleton and myosin motors are known to dynamically interact with different membrane boundaries, facilitating organelle movements and partitioning. Intriguingly, recent studies have pinpointed a special participation of actomyosin at various MCSs involving the endoplasmic reticulum (ER), the most extensive membranous organelle in the cell. Here, I summarize emerging roles of ER MCSs in modulating actomyosin structures and discuss feedback functions of such actomyosin regulation at these MCSs.
机译:真核膜结合的细胞器,表现出独特的形态,动力学和功能,通过许多束缚机械在膜接触位置(MCS)互连。 许多基本细胞过程需要MCSS,例如非囊泡脂质转移,钙运输和细胞器稳态。 已知肌动蛋白细胞骨架和肌球蛋白电动机与不同的膜边界动态相互作用,促进细胞器运动和分配。 有趣的是,最近的研究已经精确地针对涉及内质网(ER),细胞中最广泛的膜骨细胞器的各种MCS的特殊参与。 这里,我总结了ER MCS在调节肌肌素结构中的新发现作用,并讨论这些MCS中这种肌动酶调节的反馈函数。

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