...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Crystal growth & design >Structural study of prolinium/fumaric acid zwitterionic cocrystals: Focus on hydrogen-bonding pattern involving zwitterionic (Ionic) heterosynthons
【24h】

Structural study of prolinium/fumaric acid zwitterionic cocrystals: Focus on hydrogen-bonding pattern involving zwitterionic (Ionic) heterosynthons

机译：lin /富马酸两性离子共晶体的结构研究：专注于涉及两性离子（离子）杂合子的氢键模式

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pharmaceutical compounds are mostly developed as solid dosage forms containing a single crystal form. This implies that the selection of a particular crystal state for a given molecule is an important step for further clinical outlooks. Different methods can be used in the case of polymorphism issues at the time of optimal phase selection. One of the promising techniques developed these last few years is cocrystallization. In this context, proline (pyrrolidine-2-carboxylic acid) is considered in the present work. Cocrystals of proline and fumaric acid (E-butenedioic acid) are mainly analyzed by powder and single-crystal X-ray diffraction (PXRD and SCXRD, respectively). At first, the cocrystallization conditions are optimized by grinding (dry grinding), a green method for cocrystals screening and synthesis. Under specific conditions, single crystals of a 2:1 l-proline-fumaric acid racemic zwitterionic cocrystal have been obtained, an outcome confirmed by crystallographic analysis. Enantiomeric cocrystal form was obtained starting from d-proline. With the racemic compound (dl-proline), a three-component cocrystal is formed, the 1:1:1 l-proline-d-proline-fumaric acid cocrystal. Interestingly, this latter seems to be obtained using two distinct synthetic ways. Calorimetric measurements have been performed in order to establish the binary-phase diagram of the l-proline-fumaric acid cocrystal. Structural comparison with related structures from the Cambridge Structural Database revealed similarities in the crystalline network and introduced a systematic and detailed analysis of hydrogen bond interactions in zwitterionic cocrystalline structures involving proline.
机译：药物化合物大部分被开发为包含单晶形式的固体剂型。这意味着对于给定的分子选择特定的晶态是进一步临床前景的重要步骤。在最佳相位选择时，对于多态性问题，可以使用不同的方法。最近几年开发的有前途的技术之一是共结晶。在本文中，脯氨酸（吡咯烷-2-羧酸）被认为是目前的工作。脯氨酸和富马酸（E-丁烯二酸）的共晶体主要通过粉末和单晶X射线衍射（分别为PXRD和SCXRD）进行分析。首先，通过研磨（干磨）来优化共结晶条件，这是一种用于共晶筛选和合成的绿色方法。在特定条件下，获得了2：1脯氨酸-富马酸外消旋两性离子共晶体的单晶，通过晶体学分析证实了这一结果。从d-脯氨酸开始获得对映体共晶形式。与外消旋化合物（dl-脯氨酸）一起形成三组分共晶体，即1∶1∶1的l-脯氨酸-d-脯氨酸-富马酸共晶体。有趣的是，后者似乎是使用两种不同的合成方法获得的。为了建立1-脯氨酸-富马酸共晶体的二元相图，已经进行了量热法测量。与剑桥结构数据库中相关结构的结构比较揭示了晶体网络中的相似性，并介绍了涉及脯氨酸的两性离子共晶体结构中氢键相互作用的系统详细分析。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号