Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

Lovejoy K.S.; Corley C.A.; Cope E.K.; Valentine M.C.; Leid J.G.; Purdy G.M.; Wilkes J.S.; Koppisch A.T.; Del Sesto R.E.

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Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

机译：利用金属卤化物的歧义性来开发无定形的，稳定的药剂，作为离子液体

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A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl_2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

机译：一种新的策略采用了活性药物的无定形熔体，该熔体与金属氯化物（包括ZnCl_2）通过物种歧义性形成。 Lewis酸性生物无机离子液体制剂可改善保存期限和水溶性，并消除与晶体多态性有关的问题。这种广泛的方法可生产出耐热性强的金属氯酸金属盐制备物，用作乳液，抗生物膜剂，以及在不冷藏的情况下使用。

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《Crystal growth & design》 |2012年第11期|共8页
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Lovejoy K.S.; Corley C.A.; Cope E.K.; Valentine M.C.; Leid J.G.; Purdy G.M.; Wilkes J.S.; Koppisch A.T.; Del Sesto R.E.;
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正文语种 eng
中图分类晶体学;
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1. Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids [J] . Lovejoy K.S., Corley C.A., Cope E.K., Crystal growth & design . 2012,第11期

机译：利用金属卤化物的歧义性来开发无定形的，稳定的药剂，作为离子液体
2. Palladium-catalysed methylation of aryl halides in ionic liquids with stabilized AlMe3 [J] . Valeria Conte, Giulia Fiorani, Barbara Floris Applied Catalysis, A. General: An International Journal Devoted to Catalytic Science and Its Applications . 2010,第1a2期

机译：具有稳定AlMe3的离子液体中钯催化的芳基卤化物的甲基化
3. Extraction Behavior and Separation of Precious and Base Metals from Chloride, Bromide, and Iodide Media Using Undiluted Halide Ionic Liquids [J] . ACS Sustainable Chemistry & Engineering . 2020,第22期

机译：利用未稀卤离子液体的氯化物，溴化物和碘化物磷酸盐的提取行为和分离
4. Chapter 6 Organic Synthesis in Ionic Liquids Utilizing Organometallic Reagents [C] . George W. Kabalka, Bollu Venkataiah, Gang Dong Ionic liquids in organic synthesis . 2004

机译：第6章利用有机金属试剂在离子液体中进行有机合成
5. Electrochemistry of transition metal halide and oxide halide complexes in room temperature haloaluminate ionic liquids. [D] . Sun, I-Wen. 1989

机译：室温卤铝酸盐离子液体中过渡金属卤化物和氧化物卤化物配合物的电化学。
6. The Use of Liquids Ionic Fluids as Pharmaceutically Active Substances Helpful in Combating Nosocomial Infections Induced by Klebsiella Pneumoniae New Delhi Strain Acinetobacter Baumannii and Enterococcus Species [O] . Andrzej Miskiewicz, Piotr Ceranowicz, Mateusz Szymczak, 2018

机译：液体离子液体作为药物活性物质的使用有助于对抗肺炎克雷伯菌新德里菌株鲍曼不动杆菌和肠球菌引起的医院感染
7. Imidazolium ionic liquids as promoters and stabilising agents for the preparation of metal(0) nanoparticles by reduction and decomposition of organometallic complexes [O] . Prechtl M. H. G., Campbell P. S., Scholten J. D., 2010

机译：咪唑鎓离子液体作为促进剂和稳定剂，用于通过还原和分解有机金属配合物来制备金属（0）纳米粒子

Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

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