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首页> 外文期刊>Acta Histochemica: Zeitschrift fur Histologische Topochemie >Expression patterns of natriuretic peptides in pre-hibernating and hibernating anatolian ground squirrel (Spermophilus xanthoprymnus) lung
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Expression patterns of natriuretic peptides in pre-hibernating and hibernating anatolian ground squirrel (Spermophilus xanthoprymnus) lung

机译：在冬眠和冬眠的NaTrietic肽的表达模式和冬眠的Anatolian地鼠（Permophilus Xanthoprymnus）肺

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摘要

Anatolian ground squirrel (Spermophilus xanthoprymnus) is a true hibernator. This animal transiently reduces pulmonary function during hibernation. Continuance of pulmonary function is very important to survive ground squirrels during the hibernation. Natriuretic peptides may be key players in the modulation of pulmonary hemostasis. However, NPs' role in pulmonary function during hibernation remains unclear. We aimed to investigate the localization and distribution of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) in squirrel lungs during pre-hibernation and hibernation periods using immunohistochemistry. Our immunohistochemical data indicate that ANP, BNP, and CNP were produced by the mucosal epithelium of terminal and respiratory bronchioles, smooth muscle cells in the lamina propria of terminal bronchioles and vascular smooth muscle cells, alveolar type II cells, and macrophages. ANP immunoreactivity was weaker than BNP and CNP immunoreactivities in these cells. The results also demonstrate that the number of ANP, BNP and CNP positive alveolar type II cells tended to increase, although statistically non-significant, during the hibernation period, but the expression of NPs in other pulmonary cells is unaffected by hibernation. This study firstly investigates ANP, BNP and CNP distribution in the Anatolian ground squirrel lung. However, further studies are required to dissect their functional roles during the hibernation.
机译：Anatolian地鼠（Permophilus xanthoprymnus）是真正的冬眠。这种动物在冬眠期间瞬时减少肺功能。在冬眠期间，肺功能的持续是在地松鼠存活的情况下非常重要。利可钠肽可以是肺止血调节的关键球员。然而，冬眠期间肺功能中的NPS在肺功能中的作用仍不清楚。我们的旨在在使用免疫组织化学的前冬眠和冬眠期间调查心房Natrietic肽（ANP），脑流钠肽（BNP）和C型Natriesurecy肽（CNP）的定位和分布。我们的免疫组织化学数据表明，ANP，BNP和CNP由末端和呼吸支气管的粘膜上皮，层状支气管的椎相色谱和血管平滑肌细胞，肺泡II型细胞和巨噬细胞中的粘膜桥中的光滑肌细胞产生。 ANP免疫反应性比这些细胞中的BNP和CNP免疫反应性较弱。结果还证明ANP，BNP和CNP阳性肺泡II型细胞的数量倾向于增加，但在冬眠期间统计学上不显着，但在其他肺部细胞中的NP表达不受冬眠的影响。本研究首先研究了安托利亚地鼠肺中的ANP，BNP和CNP分布。然而，需要进一步的研究来对其在冬眠期间讨论其功能作用。

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