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首页> 外文期刊>Acta Neurochirurgica >Quality of life and disability 12 months after surgery vs. conservative management for unruptured brain arteriovenous malformations: Scottish population-based and Australian hospital-based studies
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Quality of life and disability 12 months after surgery vs. conservative management for unruptured brain arteriovenous malformations: Scottish population-based and Australian hospital-based studies

机译：手术后12个月的生活质量和残疾术后未破产脑动脉畸形的保守管理：基于苏格兰人口和澳大利亚医院的研究

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Abstract Background Few data are available on disability and quality of life (QOL) after surgery versus conservative management for unruptured brain arteriovenous malformations (uAVMs). Objective The aim of this study was to test the hypothesis that QOL and disability are worse after surgery?±?preoperative embolisation for uAVM compared with conservative management. Methods We included consecutive patients diagnosed with uAVM from a prospective population-based study in Scotland (1999–2003; 2006–2010) and a prospective hospital-based series in Australia (2011–2015). We assessed outcomes on the modified Rankin Scale (mRS) and the Short Form (SF)-36 at ~?12?months after surgery or conservative treatment and compared these groups using continuous ordinal regression in the two cohorts separately. Results Surgery was performed for 29% of all uAVM cases diagnosed in Scotland and 84% of all uAVM referred in Australia. There was no statistically significant difference between surgery and conservative management at 12?months among 79 patients in Scotland (mean SF-36 Physical Component Score (PCS) 39 [SD 14] vs. 39 [SD 13]; mean SF-36 Mental Component Score (MCS) 38 [SD 14] vs. 39 [SD 14]; mRS >?1, 24 vs. 9%), nor among 37 patients in Australia (PCS 51 [SD 10] vs. 49 [SD 6]; MCS 48 [SD 12] vs. 49 [SD 10]; mRS >?1, 19 vs. 30%). In the Australian series, there was no statistically significant change in the MCS and PCS between baseline before surgery or conservative management and 12?months. Conclusions We did not find a statistically significant difference between surgery?±?preoperative embolisation and conservative management in disability or QOL at 12?months.
机译：摘要背景少数数据可用于手术后的残疾和寿命质量（QOL），与盲脑动脉畸形畸形（UVMS）进行保守管理。目的是该研究的目的是测试手术后QOL和残疾更差的假设？与保守管理相比，UAVM的术前栓塞术。方法包括从苏格兰（1999-2003; 2006-2010）和澳大利亚的一名前瞻性医院系列（2011-2015）的前瞻性患者诊断患有UAVM的连续患者。我们评估了修改的Rankin规模（MRS）和短型（SF）-36的结果，在手术或保守治疗后，使用连续的序数回归分别使用连续的序数回归比较这些组。结果手术是诊断苏格兰诊断的所有UAVM病例的29％，澳大利亚所有UVM的84％。在苏格兰79名患者中，手术和保守管理之间没有统计学上显着差异（平均SF-36物理分量评分（PCS）39 [SD 14] 39 [SD 13];平均SF-36心理组分得分（MCS）38 [SD 14]与39 [SD 14];澳大利亚夫人>？1,24与37例患者（PC 51 [SD 10] [SD 6]; MCS 48 [SD 12]与49 [SD 10]; MRS>？1,19与30％）。在澳大利亚系列中，在手术前或保守管理前的基线之间的MCS和PC中没有统计上显着的变化，12个月。结论我们没有发现手术之间的统计学意义差异，在12月12日的残疾或QOL中术前渗透和保守管理。

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