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首页> 外文期刊>Acta neurologica Scandinavica. >Smoking and worsening disability in multiple sclerosis: A meta‐analysis
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Smoking and worsening disability in multiple sclerosis: A meta‐analysis

机译：在多发性硬化症中吸烟和恶化的残疾：META分析

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Objectives Multiple sclerosis ( MS ) is a chronic demyelinating disorder affecting young adults. Environmental factors and lifestyle behaviors are pivotal in MS pathophysiology. Smoking has been considered as an important risk factor in MS . Various recent studies have been conducted to measure the role of smoking on worsening disability in patients with MS , thus we intended to systematically assess effect of smoking on evolution of disability in this study. Materials & methods We queried MEDLINE , EMBASE and Cochrane Library with following keywords “Multiple Sclerosis, Smoking, Tobacco Use, Disability” on December 1st 2016. Original articles were included when smoking history was mentioned, disability was measured via expanded disability status scale ( EDSS ) or multiple sclerosis severity score ( MSSS ). Studies with insufficient outcome data, non‐human, or in other languages than English were excluded. Results Through literature review after duplicate removals, 268 articles were retrieved. A total of 56 articles were screened and 15 articles were assessed for eligibility, finally, eleven articles were included in this systematic review and meta‐analysis. Ever smoking was significantly associated with increased EDSS (standardized mean difference ( SMD )?=?0.15, 95% CI ?=?0.01‐0.28), but had no significant association with risk of reaching EDSS 4 ( HR ?=?1.24, 95% CI ?=?0.89‐1.72) or EDSS 6 ( HR ?=?1.17, 95% CI ?=?0.88‐1.57). Smoking had no effect on MSSS ( SMD ?=?0.14, 95% CI ?=??0.04‐0.32) or T2 lesion volume ( SMD ?=?0.07, 95% CI ?=??0.08‐0.22). Conclusions This meta‐analysis showed smoking increased EDSS , insignificant findings were possibly due to the small number of studies, significant differences in methodologies, and variations in reporting of disability outcomes.
机译：目标多发性硬化症（MS）是一种影响年轻成年人的慢性脱髓鞘疾病。环境因素和生活方式行为是MS病理生理学的关键。吸烟被认为是MS中的重要危险因素。已经进行了各种最近的研究，以衡量吸烟对MS患者残疾的作用，因此我们旨在系统地评估吸烟对本研究中残疾演变的影响。材料＆amp;方法探讨了Medline，Embase和Cochrane图书馆的关键词“多发性硬化，吸烟，烟草使用，残疾”。原始物品被列入吸烟历史时，通过扩大的残疾状态规模（EDS）或多发性硬化症严重程度评分（MSSS）。除了英语之外，没有足够的结果数据，非人类或其他语言的研究。通过重复除去后的文献综述，检测268篇文章。筛选了56篇文章，并评估了15篇文章，最后，在该系统审查和荟萃分析中纳入11篇文章。曾经吸烟与增加的EDSS显着相关（标准化平均差异（SMD）？=？0.15,95％CI？=？0.01-0.28），但与达到EDSS 4的风险没有显着关联（HR？=？1.24,95 ％ci？=？0.89-1.72）或Eds 6（Hr？=α1.17,95％ci？= 0.88-1.57）。吸烟对MSSS没有影响（SMD？= 0.14,95％CI？= ?? 0.04-0.32）或T2病变体积（SMD？= 0.07,95％CI？= ?? 0.08-0.22）。结论这种荟萃分析显示吸烟增加的EDS，可能是由于少数研究，方法差异以及报告残疾事件的变化可能是缺乏的。

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