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Sequential drug delivery for liver diseases

机译：肝病的顺序药物递送

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The liver performs critical physiological functions such as metabolism/detoxification and blood homeostasis/bil-iary excretion. A high degree of blood access means that a drug's resident time in any cell is relatively short. This short drug exposure to cells requires local sequential delivery of multiple drugs for optimal efficacy, potency, and safety. The high metabolism and excretion of drugs also impose both technical challenges and opportunities to sequential drug delivery. This review provides an overview of the sequential events in liver regeneration and the related liver diseases. Using selected examples of liver cancer, hepatitis B viral infection, fatty liver diseases, and drug-induced liver injury, we highlight efforts made for the sequential delivery of small and macromolecular drugs through different biomaterials, cells, and microdevice-based delivery platforms that allow fast delivery kinetics and rapid drug switching. As this is a nascent area of development, we extrapolate and compare the results with other sequential drug delivery studies to suggest possible application in liver diseases, wherever appropriate.
机译：肝脏表现出关键的生理功能，例如新陈代谢/排毒和血腥的稳态/ BIL-IRY排泄。高度的血液接入意味着药物在任何细胞中的居民时间相对较短。这种短的药物暴露于细胞需要局部顺序递送多种药物，以获得最佳的疗效，效力和安全性。毒品的高代谢和排泄也施加了技术挑战和序列药物递送的机会。本综述概述了肝再生中的顺序事件和相关肝病。使用肝癌的选定实例，乙型肝炎病毒感染，脂肪肝疾病和药物诱导的肝损伤，我们突出了通过不同的生物材料，细胞和基于微小的递送平台来突出的努力来通过不同的生物材料，细胞和基于微分子药物的递送快速交付动力学和快速药物切换。由于这是一种新生的发展领域，我们将结果与其他顺序药物递送研究结合并与其他顺序药物递送研究表明，在适当的情况下表明可能在肝脏疾病中的应用。

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