...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced drug delivery reviews >Adenosine and lipids: A forced marriage or a love match?
【24h】

Adenosine and lipids: A forced marriage or a love match?

机译：腺苷和脂质：强迫婚姻或爱情匹配？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adenosine is a fascinating compound, crucial in many biochemical processes: this ubiquitous nucleoside serves as an essential building block of RNA, is also a component of ATP and regulates numerous pathophysiological mechanisms via binding to four extracellular receptors. Due to its hydrophilic nature, it belongs to a different world than lipids, and has no affinity for them. Since the 1970's, however, new discoveries have emerged and prompted the scientific community to associate adenosine with the lipid family, especially via liposomal preparations and bioconjugation. This seems to be an arranged marriage, but could it turn into a true love match? This review considered all types of unions established between adenosine and lipids. Even though exciting supramolecular structures were observed with adenosine-lipid conjugates, as well as with liposomal preparations which resulted in promising pre-clinical results, the translation of these technologies to the clinic is still limited.
机译：腺苷是一种迷人的化合物，在许多生化过程中至关重要：这种普遍存在的核苷作为RNA的基本结构块，也是ATP的组分，通过结合四种细胞外受体来调节许多病理生理机制。 由于其亲水性，它属于不同的世界，而不是脂质，对它们没有亲和力。 然而，自1970年代以来，已经出现了新的发现，并促使科学界与脂质家族联系在脂质家族，特别是通过脂质体制剂和生物杂交。 这似乎是一个安排的婚姻，但它可以变成一个真正的爱情比赛？ 这篇综述综述腺苷和脂质之间建立的各种工会。 尽管用腺苷 - 脂质缀合物观察到激发的超分子结构，以及导致临床前结果的脂质体制剂，但对临床临床翻译仍然有限。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号