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Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges

机译：凝固以改善潜水的生物武装表现：机遇和挑战

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Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. The development of intelligent hybrid drug formulations has presented new opportunities to harness the potential of emulsified lipids in optimising oral bioavailability for lipophilic therapeutics. Specific emphasis of this review is placed on the impact of solidification approaches and excipients on the biopharmaceutical performance of self-emulsifying lipids, with findings highlighting the key design considerations that should be implemented when developing hybrid lipid-based formulations. (C) 2018 Elsevier B.V. All rights reserved.
机译：自乳化药物递送系统（SEDDS）通过在胃肠过渡期间将它们保留在增溶状态下克服疏水性药物的固有缓慢溶解和口服不良，提供潜力。然而，由于它们对长期储存和体内降水问题的易感性，液体脂质制剂的有希望的液体脂质制剂的生物制药益处并未转化为广泛的商业成功。出现了一种克服这些限制的一种策略是将溶解和溶解增强了脂质的稳定性和固体载体材料的稳定作用。智能杂种药物制剂的发展提出了利用乳化脂质的潜力在优化脂肪酸治疗中的口服生物利用度方面提出了新的机会。本综述的具体重点是凝固方法和赋形剂对自乳化脂质的生物制药性能的影响，调查结果突出了应在开发杂种脂质的配方时应实施的关键设计考虑因素。 （c）2018 Elsevier B.v.保留所有权利。

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