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首页> 外文期刊>Acta Radiologica >Whole-body MRI added to gadoxetic acid-enhanced liver MRI for detection of extrahepatic disease in patients considered eligible for hepatic resection and/or local ablation of colorectal cancer liver metastases
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Whole-body MRI added to gadoxetic acid-enhanced liver MRI for detection of extrahepatic disease in patients considered eligible for hepatic resection and/or local ablation of colorectal cancer liver metastases

机译：全身MRI加入乙酰基酸增强的肝脏MRI中，用于检测患者患者患者的嗜肝疾病和/或结直肠癌肝转移酶的局部消融

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Background Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can detect extrahepatic disease before local treatment of colorectal liver metastases. Purpose To investigate if whole-body magnetic resonance imaging (MRI) added to gadoxetic acid liver MRI could replace FDG-PET/CT for detection of extrahepatic disease in patients with colorectal liver metastases eligible for hepatic local treatment. Material and Methods This health-research-ethics-committee-approved prospective consecutive diagnostic accuracy study with written informed consent analyzed 79 cases included between 29 June 2015 and 7 February 2017. Whole-body MRI covering the thorax, abdomen, and pelvis and FDG-PET/CT including contrast-enhanced CT was performed 0-3 days before local treatment of liver metastases. Whole-body MR images were read independently by two readers. FDG-PET/CT images were read independently by two pairs of readers. Histopathology and follow-up imaging were used as reference standard. Sensitivities and specificities were calculated and compared including noninferiority analysis. Results Seventy-five malignant lesions and 419 benign lesions were confirmed. Sensitivities of both PET/CT reader pairs 1 and 2 (56.7 and 67.9%) and MRI reader 2 (63.0%) were significantly higher than that of MRI reader 1 (42.7) (P<0.04). Specificities of both PET/CT reader pairs 1 and 2 (92.5 and 92.4%) and MRI reader 1 (91.1%) were significantly higher than that of MRI reader 2 (86.3%) (P < 0.02). Sensitivity of MRI reader 2 was non-inferior compared to PET/CT reader pair 1. Specificities of both MRI readers were non-inferior to both PET/CT reader pairs. Conclusion For detection of extrahepatic disease in patients with colorectal liver metastases, whole-body MRI was non-inferior to FDG-PET/CT for some reader combinations. However, reader-independent non-inferiority could not be demonstrated.
机译：背景技术氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET / CT）可以在局部治疗结直肠肝转移之前检测脱胸部疾病。为了研究添加到乙酰基酸性肝脏MRI的全体磁共振成像（MRI）可以代替FDG-PET / CT，用于检测患有肝脏局部治疗的结肠直肠肝转移患者的脱脓性疾病。材料和方法这种健康研究 - 道德委员会核准的前瞻性连续诊断准确性研究与书面知情同意书分析了79例案件2015年6月29日和2017年2月7日。覆盖胸部，腹部和骨盆和FDG的全身MRI-在肝转移酶局部治疗前进行对比增强CT的PET / CT。全身MR图像由两个读者独立读取。通过两对读取器独立读取FDG-PET / CT图像。组织病理学和后续成像用作参考标准。计算敏感性和特异性并进行比较，包括非流体分析。结果证实了七十五个恶性病变和419例良性病变。 PET / CT读取器对1和2（56.7和67.9％）和MRI阅读器2（63.0％）的敏感性显着高于MRI读卡器1（42.7）（P <0.04）。 PET / CT读取器对1和2（92.5和92.4％）和MRI读者1（91.1％）的特异性显着高于MRI读者2（86.3％）（P <0.02）。与PET / CT读取器对相比，MRI读取器2的敏感性是非较差的1.MRI读者的特异性对PET / CT读卡器对不逊色。结论检测结直肠肝转移患者肝外疾病，全身MRI对FDG-PET / CT进行了一些读者组合。但是，无法证明读者无关的非劣效性。

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