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首页> 外文期刊>Acta Radiologica >Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers
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Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers

机译：洗涤/洗涤阶段Xenon增强区域检测器CT（ADCT）：用于区域通风，肺功能损失和吸烟者临床阶段评估的效用

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Background Xenon (Xe)-enhanced area-detector computed tomography (ADCT) can visualize regional distribution of Xe within the lungs and demonstrate regional ventilation differences in smokers and patients with pulmonary diseases. Purpose The purpose of this study was to evaluate the capability of wash-in and wash-out (WI/WO) phase Xe-enhanced ADCT for detecting regional ventilation differences based on underlying lung conditions, pulmonary functional loss evaluation, and clinical stage prediction for smokers with and without chronic obstructive pulmonary disease (COPD). Material and Methods The pulmonary function test as well as inspiratory/expiratory unenhanced and WI/WO phase Xe-enhanced ADCT were prospectively administered to a group of 40 smokers consisting of 25 men (mean age +/- standard deviation [SD] = 65.1 +/- 9.5 years) and 15 women (65.2 +/- 9.4 years), after which WI, WO, WI/WO ratio, and ventilation ratio as well as parametric response maps were generated. All Xe-enhanced ADCT indexes and pulmonary function test results were subjected to step-wise regression analyses. Finally, discrimination analysis was performed to determine the concordance capability for clinical stage classification of smokers. Results %VC was significantly affected by the WI index (P < 0.0001), while FEV1/FVC% and %FEV1 were significantly affected by the ventilation ratio (P < 0.0001). Accuracy of the WI index combined with the ventilation ratio was significantly higher than that of the WI index (P = 0.008), WI/WO ratio (P = 0.02), and WI index combined with the WI/WO ratio (P = 0.02). Conclusion WI/WO phase Xe-enhanced ADCT is useful for assessing smoking-related regional ventilation change and pulmonary functional loss, as well as evaluating the severity of smokers' diseases.
机译：背景技术氙气（XE） - 纳米探测器计算断层扫描（ADCT）可以在肺部内容可视化XE的区域分布，并展示吸烟者和肺病患者的区域通风差异。目的本研究的目的是评估洗涤和洗涤（WI / WO）相XE增强的ADCT的能力，用于检测基于潜在肺部条件，肺功能损失评估和临床预测的区域通气差异没有慢性阻塞性肺病（COPD）的吸烟者。材料和方法肺功能测试以及吸气/呼气的未加入和WI / WO / WO / WO期XE增强ADCT预期给予一组40名由25名男性组成的吸烟者（平均年龄+/-标准偏差[SD] = 65.1 + / - 9.5岁）和15名女性（65.2 +/- 9.4岁），之后产生Wi，Wo，Wi / Wo比和通风率以及参数响应图。所有XE增强的ADCT指标和肺功能测试结果都经受了逐步的回归分析。最后，进行歧视分析以确定吸烟者临床阶段分类的一致性能力。结果VC受Wi指数的显着影响（P <0.0001），而FEV1 / FVC％和％FEV1受通气率的显着影响（P <0.0001）。与通风率相结合的WI指数的精度明显高于WI指数（P = 0.008），WI / WO比（P = 0.02）和Wi指数与Wi / Wo比率相结合（p = 0.02） 。结论WI / WO期XE增强ADCT可用于评估吸烟有关的区域通风变化和肺功能丧失，以及评估吸烟者疾病的严重程度。

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