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首页> 外文期刊>Acta Radiologica >Intravoxel incoherent motion imaging in monitoring the function of kidney allograft
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Intravoxel incoherent motion imaging in monitoring the function of kidney allograft

机译：监测肾同种异体移植功能的膀胱内杂环间运动成像

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Background Non-invasive alternatives to percutaneous renal biopsy are sought for follow-up of renal allografts. Purpose To evaluate the feasibility of intravoxel incoherent motion (IVIM) imaging in monitoring and predicting the function of renal allografts. Material and Methods Thirty-five kidney recipients were examined on a 1.5-T MR unit approximately three and 18 months after transplantation. Based on estimated glomerular filtration rate (eGFR), patients were divided into three groups: improved; declined; and stable graft function. Diffusion parameters were calculated with the use of monoexponential (total apparent diffusion coefficient [ADC(T)]) and biexponential (pure diffusion coefficient [D], perfusion fraction [Fp]) model and compared among and within study groups using Kruskal-Wallis, Mann-Whitney, and Wilcoxon matched pairs tests. Diffusion parameters were correlated with eGFR using Spearman's rank correlation coefficients. Results of tests with P values < 0.05 were considered statistically significant. Results Values of diffusion parameters, especially Fp, were lower in patients with a declined graft function; however, statistically significant intergroup differences were observed only in a limited number of parameters at the time of follow-up magnetic resonance imaging (MRI). None of the diffusion parameters from the baseline MRI correlated with the change in eGFR over time. Flow-related diffusion parameters calculated with the IVIM model showed high variability. Conclusion We observed a trend toward a decrease in values of diffusion parameters in patients with a declined graft function. Further research is needed to verify a clinical usefulness of this observation.
机译：寻求肾同种异体移植物的后续肾激素的背景非侵入性替代品。目的，评价透析性非相干运动（IVIM）成像在监测和预测肾同种异体移植函数中的可行性。在移植后约3和18个月，在1.5-T MR单元上检查材料和方法35个肾脏受体。基于估计的肾小球过滤速率（EGFR），患者分为三组：改进;拒绝;稳定的移植功能。通过使用单烯烃（纯显式扩散系数[ADC（T）]）和Biexponential（纯扩散系数[D]，灌注级分[FP]）模型来计算扩散参数，并使用Kruskal-Wallis进行比较和研究组中， Mann-Whitney和Wilcoxon匹配对测试。扩散参数与EGFR使用Spearman的等级相关系数相关。 P值<0.05的试验结果被认为是统计学意义。结果扩散参数，尤其是FP，患者的衰减接枝函数较低;然而，在随访磁共振成像（MRI）时，仅在有限数量的参数中观察到统计学上显着的相互作用的差异。基线MRI中没有扩散参数与EGFR的变化随时间相关。随着IVIM模型计算的流量相关的扩散参数显示出高的变化性。结论我们观察到患者衰减接枝功能的扩散参数减少的趋势。需要进一步研究来验证这种观察的临床有用性。

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