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首页> 外文期刊>Acta Radiologica >Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model
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Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model

机译：小鼠胚胎脉络膜瘤瘤模型微血管特征的椎间杂志不相干运动扩散加权成像评估

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Background Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can distinguish the false diffusion generated by microvascular blood flow from the true water molecule diffusion. Purpose To investigate the correlation between IVIM-DWI parameters and angiogenic markers such as the microvessel density and vascular endothelial growth factor (VEGF) expression in the murine embryonal rhabdomyosarcoma model. Material and Methods The murine embryonal rhabdomyosarcoma model was produced by subcutaneously injecting 10(7) human embryonal rhabdomyosarcoma cells into the right back of nude mice. The apparent diffusion coefficient (ADC), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and perfusion fraction (f) were obtained from 22 mice models using IVIM-DWI with b-values of 0, 50, 100, 150, 200, 400, 600, 800, 1000, and 1200 s/mm(2). The microvessel density and VEGF expression were obtained by histologic examination. We then compared the correlation between IVIM-DWI parameters and microvessel density and VEGF expression. Results The average ADC, D*, D, and f values were 1.05 +/- 0.27 x 10(-3) mm(2)/s, 6.19 +/- 1.78 x 10(-3) mm(2)/s, 0.69 +/- 0.09 x10(-3) mm(2)/s, and 17.68 +/- 8.41 (%), respectively. There was moderate positive correlation between D* value and microvessel density and VEGF expression (r = 0.484, P = 0.023; r = 0.511, P = 0.015). However, there was no significant correlation between ADC, D, and f values and microvessel density and VEGF expression. Conclusion The D* value from IVIM-DWI may be used to evaluate tumor angiogenesis in the murine embryonal rhabdomyosarcoma model.
机译：背景技术跨还是跨越的运动扩散加权成像（IVIM-DWI）可以区分通过从真水分子扩散的微血管血流产生的错误扩散。目的探讨鼠胚胎脉络膜模型中的IVIM-DWI参数和血管生成标记物等血管生成标记（血管内皮生长因子（VEGF）表达的相关性。材料和方法通过将10（7）人胚胎横纹骨肉瘤细胞皮下注射到裸鼠的右后产生鼠胚胎横纹肌肉瘤模型。从22只小鼠模型使用IVIM-DWI，B值为0,50,100 ，150,200,400,600,800,000和1200 s / mm（2）。通过组织学检查获得微血管密度和VEGF表达。然后，我们比较了IVIM-DWI参数和微血管密度与VEGF表达之间的相关性。结果平均ADC，D *，D和F值为1.05 +/- 0.27×10（-3）mm（2）/ s，6.19 +/- 1.78 x 10（-3）mm（2）/ s， 0.69 +/- 0.09 X10（-3）mm（2）/ s，分别为17.68 +/- 8.41（％）。 D *值和微血管密度和VEGF表达之间存在适度的正相关（r = 0.484，p = 0.023; r = 0.511，p = 0.015）。然而，ADC，D和F值与微血管密度与VEGF表达之间没有显着相关性。结论IVIM-DWI的D *值可用于评估小鼠胚胎脉络膜模型中的肿瘤血管生成。

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