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首页> 外文期刊>Acta Radiologica >Quantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction maps
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Quantitative PET/MR imaging of lung cancer in the presence of artifacts in the MR-based attenuation correction maps

机译：肺癌在MR基衰减校正图中肺癌的定量宠物/ MR成像

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Background Positron emission tomography (PET)/magnetic resonance (MR) imaging may become increasingly important for assessing tumor therapy response. A prerequisite for quantitative PET/MR imaging is reliable and repeatable MR-based attenuation correction (AC). Purpose To investigate the frequency and test-retest reproducibility of artifacts in MR-AC maps in a lung cancer patient cohort and to study the impact of artifact corrections on PET-based tumor quantification. Material and Methods Twenty-five lung cancer patients underwent single-day, test-retest, F-18-fluorodeoxyglucose (FDG) PET/MR imaging. The acquired MR-AC maps were inspected for truncation, susceptibility, and tissue inversion artifacts. An anatomy-based bone template and a PET-based estimation of truncated arms were employed, while susceptibility artifacts were corrected manually. We report the frequencies of artifacts and the relative difference (RD) on standardized uptake value (SUV) based quantification in PET images reconstructed with the corrected AC maps. Results Truncation artifacts were found in all 50 acquisitions (100%), while susceptibility and tissue inversion artifacts were observed in six (12%) and 26 (52%) of the scans, respectively. The RD in lung tumor SUV was < 5% from bone and truncation corrections, while up to 20% RD was introduced after susceptibility artifact correction, with large inconsistencies between test-retest scans. Conclusion The absence of bone and truncation artifacts have limited effect on the PET quantification of lung lesions. In contrast, susceptibility artifacts caused significant and inconsistent underestimations of the lung tumor SUVs, between test-retest scans. This may have clinical implications for patients undergoing serial imaging for tumor therapy response assessment.
机译：背景技术正电子发射断层扫描（PET）/磁共振（MR）成像可能对评估肿瘤治疗反应越来越重要。定量PET / MR成像的先决条件是可靠和可重复的MR基衰减校正（AC）。目的探讨肺癌患者队列MR-AC地图中伪影的频率和测试 - 重度再现性，研究伪影校正对宠物基肿瘤定量的影响。材料与方法二十五肺癌患者经过单日，试验 - 重试，F-18-氟脱氧氧（FDG）PET / MR成像。检查了所获取的MR-AC地图以进行截断，敏感性和组织反转伪影。采用基于解剖学的骨模板和基于PET的截断臂的估计，而手动校正易感术。我们在用校正的AC地图重建的PET图像中的基于标准化摄取值（SUV）的量化的伪影和相对差异（RD）的频率。结果在所有50个采集（100％）中发现截断伪影，而分别在六（12％）和26（52％）的扫描中观察到敏感性和组织反转伪影。肺肿瘤SUV中的RD源于骨和截断校正的5％，在易感性伪影校正后引入高达20％的RD，在测试 - 重保持扫描之间具有较大的不一致。结论骨骼和截断文物的缺失对肺病变的宠物量化有限。相比之下，易感性伪影在测试 - 重保持扫描之间引起肺肿瘤SUV的显着和不一致的低估。这可能对接受肿瘤治疗响应评估的连续成像的患者具有临床意义。

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