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首页> 外文期刊>Crystal growth & design >Crystallization-based resolution process for the 2,3-dibenzoyl-D/L-tartrate salts of D-/L-serine benzyl ester
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Crystallization-based resolution process for the 2,3-dibenzoyl-D/L-tartrate salts of D-/L-serine benzyl ester

机译：D- / L-丝氨酸苄酯的2,3-二苯甲酰基-D / L-酒石酸盐的基于结晶的拆分过程

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摘要

It is shown that the 2,3-dibenzoyl-d-/l-tartrate salts of d-/l-serine benzyl ester (salt pair 1, l-d,d-d; salt pair 2, d-l,l-l) behave like simple eutectic systems in their binary (melting) and ternary (solubility) systems. Due to this essential thermodynamic property, these salts are separable via crystallization. Metastable zone width data for primary nucleation of both salts were measured to support a rational process design. Resolution processes for both salt pairs were designed and executed successfully delivering diastereomeric salts in high purity. The presence of excesses of resolving agents, previously not considered, was systematically studied and found to possess the potential to further improve the performance of the selective crystallization processes.
机译：结果表明，d- / l-丝氨酸苄酯的2,3-二苯甲酰基-d- / l-酒石酸盐（盐对1，ld，dd;盐对2，dl，ll）的行为类似于简单的共晶体系。他们的二元（熔融）和三元（溶解度）系统。由于这种基本的热力学性质，这些盐可通过结晶分离。测量了两种盐的一次成核的亚稳区域宽度数据，以支持合理的工艺设计。设计并执行了两种盐对的拆分过程，成功交付了高纯度的非对映异构盐。系统地研究了以前未考虑的过量拆分剂的存在，发现其具有进一步改善选择性结晶工艺性能的潜力。

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