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首页> 外文期刊>Crystal growth & design >Pharmaceutical co-crystals of pyrazinecarboxamide (PZA) with various carboxylic acids: Crystallography, hirshfeld surfaces, and dissolution study
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Pharmaceutical co-crystals of pyrazinecarboxamide (PZA) with various carboxylic acids: Crystallography, hirshfeld surfaces, and dissolution study

机译：吡嗪酰胺（PZA）与各种羧酸的药物共晶体：晶体学，希尔斯菲尔德表面和溶出度研究

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摘要

Three new pharmaceutical co-crystals: 1 PZA-MA (malonic acid), 2 PZA-SA (succinic acid, a new polymorph of a reported one), and 3 PZA-GA (glutaric acid) have been prepared and characterized by differential scanning calorimetry (DSC), thermogravimetric analyses (TGA), and single-crystal X-ray diffraction. Wherein, PZA formed 1:1 co-crystals with MA and GA by acid-amide and acid-py heterosynthon, while it formed 2:1 co-crystal with SA by amide-amide homosynthon in addition to acid-amide and acid-py heterosynthon. Their melting points follow the order, PZA-GA < PZA-MA < PZA-SA, which are lower than the melting points of the individual components. Hirshfeld surface analysis revealed that N-H?O hydrogen bonding and π?π interactions for PZA in them follow the order: PZA-MA > PZA-SA > PZA-GA, while H-H and O-O interactions follow the order: PZA-MA < PZA-SA < PZA-GA. We also compared the Hirshfeld surfaces of the present co-crystals with the nine reported PZA co-crystals, which obtained important results. The studies of the solubility and dissolution showed a semiempirical inverse relationship with the melting point: the solubility follows the order, PZA-SA < PZA-GA < PZA-MA and dissolution rate follows the order, PZA-SA < PZA-MA < PZA-GA.
机译：制备了三种新的药物共晶体：1种PZA-MA（丙二酸），2种PZA-SA（琥珀酸，一种已报道的新多晶型物）和3种PZA-GA（戊二酸），并通过差示扫描表征热量分析（DSC），热重分析（TGA）和单晶X射线衍射。其中，PZA通过酸酰胺和酸-py杂合子与MA和GA形成1：1共晶，而除了酰胺和酸-py以外，通过酰胺-酰胺高合子与SA形成2：1共晶。杂合子它们的熔点遵循以下顺序：PZA-GA PZA-SA> PZA-GA，而HH和OO相互作用遵循以下顺序：PZA-MA

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