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首页> 外文期刊>Advanced Science Letters >Distribution of HLA Class II Antigen in Renal Transplant Patients and Donors Visiting Tertiary Care Hospital of Karnataka State in South India
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Distribution of HLA Class II Antigen in Renal Transplant Patients and Donors Visiting Tertiary Care Hospital of Karnataka State in South India

机译：肾移植患者HLA II级抗原的分布，南印度卡纳塔克邦州三级护理医院

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摘要

Renal transplantation is the most successful treatment option for chronic renal failure patients. But success of any transplantation depends on HLA antigen matching between the recipient and the donor. This study is the first report from Karnataka state of South India to find out distributionof HLA-class II antigens in live renal transplant recipients and donors visiting a tertiary care hospital. In this study, HLA-DR allele frequencies were studied in 314 renal transplant recipients and donors visited our hospital, during 2005–2013. HLA tissue typing was done by polymerasechain reaction using sequence specific primers. Then antigen frequencies were obtained and analyzed. A total of 32 HLA-DRB1 alleles were identified in the renal transplant recipients and donors. High frequency DRB1 alleles found in our patients and donors were DRB1 * 15(25.4%), DRB1 * 14(12.2%),DRB1 * 04(11.3%), DRB1 * 13(10.2%), DRB1 * 07(8.3%). DRB1 * 15 allele was the most frequent DRB1 antigen in both males and females. Also we have found that females outnumbered males among the donors. The results showed significant heterogeneity in HLA-DRB1 alleles. The most frequent HLA-DRB3,DRB4, DRB5 alleles we observed are DRB3 * 01/02, DRB4 * 01, DRB5 * 01/02 respectively.
机译：肾移植是慢性肾功能衰竭患者最成功的治疗选择。但任何移植的成功取决于接受者和供体之间的HLA抗原匹配。本研究是南印度卡纳塔克邦的第一个报告，发现HLA-II级抗原在活肾移植受者和捐助者访问第三级护理医院的抗原。在这项研究中，在2005 - 2013年期间，在314名肾移植受者和捐助者中研究了HLA-DR等位基因频率。使用序列特异性引物通过聚合物反应完成HLA组织键入。然后获得并分析抗原频率。在肾移植受者和捐助者中鉴定了总共32个HLA-DRB1等位基因。我们患者和供体中发现的高频DRB1等位基因是DRB1 * 15（25.4％），DRB1 * 14（12.2％），DRB1 * 04（11.3％），DRB1 * 13（10.2％），DRB1 * 07（8.3％） 。 DRB1 * 15等位基因是男性和女性中最常见的DRB1抗原。此外，我们发现女性在捐助者之间数量超过雄性。结果表明HLA-DRB1等位基因中具有显着的异质性。我们观察到的最常见的HLA-DRB3，DRB4，DRB5等位基因分别是DRB3 * 01/02，DRB4 * 01，DRB5 * 01/02。

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