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首页> 外文期刊>Crystal growth & design >Four Polyoxonibate-Based Inorganic?Organic Hybrids Assembly from Bicapped Heteropolyoxonibate with Effective Antitumor Activity
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Four Polyoxonibate-Based Inorganic?Organic Hybrids Assembly from Bicapped Heteropolyoxonibate with Effective Antitumor Activity

机译：具有有效抗肿瘤活性的四价基于异多氧合己酸酯的基于多氧合己酸酯的无机或有机杂种组装体

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Four novel heteropolyoxonibate-based inorganic? organic hybrids {Cu(en)_2}_6{GeNb_(12)V~(IV)_2O_(42)}·20H_2O (1), {Cu(en)_2}_3K_2Na_4{GeNb_(12)V~(IV)_2O_(42)}·23H_2O (2), {Cu- (en)_2 } 6{SiNb1 2VI V_2O4 2 } ·18H_2O (3), and {Cu- (en)_2}_3K_2Na_4{SiNb_(12)V~(IV)_2O_(42)}·19H_2O (4) (en = ethanediamine), composed of polyoxoanions [TNb_(12)O_(40)]16? (T = Si and Ge) and [Cu(en)_2]~(2+) building blocks, were successfully synthesized under hydrothermal conditions by reaction of K_7HNb_6O_(19)·13H_2O, Cu(Ac)_2·3H_2O, Na_2VO_3, Na_2 SiO_3, or GeO_2 and en molecules. Polyoxoanion [TNb_(12)V~(IV)_2O_(42)]_(12)? (T = Si and Ge) can be best described as a α-Keggin core [TNb_(12)O_(40)] with two [VO] units capping on its two “opened windows”. Compounds 1 and 3 are both composed of the bicapped heteropolyoxonibate core surrounded by a shell consisting of twelve [Cu(en)_2]~(2+) groups, which represent a promising structural model toward core?shell nanostructures. Compounds 2 and 4 are also composed of a bicapped polyoxoanion [TNb_(12)V~(IV) 2O_(42)]_(12)? (T = Si, Ge) decorated by three metal? organic fragments [Cu(en)_2]~(2+), forming a trisupporting polyoxoanion {[Cu(en)_2]_3[TNb_(12)O_(42)V~(IV) 2]}_6?. Antitumor, electrochemical study, and UV?vis spectra indicate that compounds 1?4 exhibit effective antitumor activity against SGC7901 cells and HepG2 cells and could keep the structural integrity in this process.
机译：四种新型的基于杂多酸异壬酸酯的无机物？有机杂种{Cu（en）_2} _6 {GeNb_（12）V〜（IV）_2O_（42）}·20H_2O（1），{Cu（en）_2} _3K_2Na_4 {GeNb_（12）V〜（IV）_2O_ （42）}·23H_2O（2），{Cu-（en）_2} 6 {SiNb1 2VI V_2O4 2}·18H_2O（3）和{Cu-（en）_2} _3K_2Na_4 {SiNb_（12）V〜（IV） ）_2O_（42）}·19H_2O（4）（en =乙二胺），由多氧阴离子[TNb_（12）O_（40）] 16组成。在水热条件下，通过K_7HNb_6O_（19）·13H_2O，Cu（Ac）_2·3H_2O，Na_2VO_3，Na_2反应成功合成了（T = Si和Ge）和[Cu（en）_2]〜（2+）结构单元SiO_3或GeO_2和en分子。多氧阴离子[TNb_（12）V〜（IV）_2O_（42）] _（12）？ （T = Si和Ge）可以最好地描述为α-Keggin核[TNb_（12）O_（40）]，其两个“打开的窗口”上有两个[VO]单元。化合物1和3均由二环杂多氧羰基酸酯核心和被12个[Cu（en）_2]〜（2+）基团组成的壳包围，代表了有希望的核壳纳米结构模型。化合物2和4也由二元的聚氧阴离子[TNb_（12）V〜（IV）2O_（42）] _（12）？ （T = Si，Ge）由三种金属装饰？有机碎片[Cu（en）_2]〜（2+），形成三支撑聚氧阴离子{[Cu（en）_2] _3 [TNb_（12）O_（42）V〜（IV）2]} _ 6?。抗肿瘤，电化学研究和紫外可见光谱表明，化合物1〜4对SGC7901细胞和HepG2细胞具有有效的抗肿瘤活性，并可以在此过程中保持结构完整性。

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