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首页> 外文期刊>Crystal growth & design >In Situ Monitoring of Cocrystallization of Salicylic Acid?4,4′-Dipyridyl in Solution Using Raman Spectroscopy
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In Situ Monitoring of Cocrystallization of Salicylic Acid?4,4′-Dipyridyl in Solution Using Raman Spectroscopy

机译：水杨酸？4,4'-联吡啶在溶液中共结晶的拉曼光谱原位监测

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摘要

In situ analysis using Raman spectroscopy was used to monitor the cocrystallization process. Raman spectroscopy in the cocrystallization of acetylsalicylic acid (ASA) and 4,4′-dipyridyl(4DP) in solution was investigated. A 2:1 salicylic acid (SAA)?4DP cocrystal was identified from crystallographic data obtained by X-ray single-crystal diffraction meter. In addition, Raman spectroscopy provided additional information on crystal structure of SAA?4DP cocrystal. Raman spectra peaks of ASA?4DP solution and SAA?4DP cocrystal were observed during crystallization. By the intensity of the peaks selected, nucleation and growth of cocrystal in solution were monitored. As a result, formation of new cocrystal using aspirin and 4DP was successfully monitored by Raman spectroscopy.
机译：使用拉曼光谱法的原位分析用于监测共结晶过程。研究了溶液中乙酰水杨酸（ASA）和4,4'-联吡啶（4DP）共结晶的拉曼光谱。从通过X射线单晶衍射仪获得的晶体学数据鉴定出2∶1水杨酸（SAA）→4DP共晶体。另外，拉曼光谱提供了有关SAA 4DP共晶体的晶体结构的附加信息。在结晶过程中观察到ASA 4DP溶液和SAA 4DP共晶体的拉曼光谱峰。通过所选峰的强度，监测溶液中共晶的成核和生长。结果，通过拉曼光谱法成功监测了使用阿司匹林和4DP形成新的共晶体。

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