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Comprehending the Formation of Eutectics and Cocrystals in Terms of Design and Their Structural Interrelationships

机译：从设计及其结构相互关系理解共晶和共晶的形成

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The phenomenon of cocrystallization, which encompasses the art of making multicomponent organic solids such as cocrystals, solid solutions, eutectics, etc. for novel applications, has been less studied in terms of reliably and specifically obtaining a desired cocrystallization product and the issues that govern their formation. Further, the design, structural, and functional aspects of organic eutectics have been relatively unexplored as compared to solid solutions and cocrystals well-established by crystal engineering principles. Recently, eutectics were proposed to be designable materials on par with cocrystals, and herein we have devised a systematic approach, based on the same crystal engineering principles, to specifically and desirably make both eutectics and cocrystals for a given system. The propensity for strong homomolecular synthons over weak heteromolecular synthons and vice versa during supramolecular growth was successfully utilized to selectively obtain eutectics and cocrystals, respectively, in two model systems and in two drug systems. A molecular level understanding of the formation of eutectics and cocrystals and their structural interrelationships which is significant from both fundamental and application viewpoints is discussed. On the other hand, the obscurity in establishing a low melting combination as a eutectic or a cocrystal is resolved through phase diagrams.
机译：共结晶现象涉及为新颖的应用制造多组分有机固体（如共晶体，固溶体，低共熔晶体等）的技术，但在可靠和具体地获得所需的共结晶产物以及控制它们的问题方面，研究较少。编队。此外，与通过晶体工程原理很好地建立的固溶体和共晶体相比，有机共晶的设计，结构和功能方面还相对未被开发。近来，共晶被认为是可与共晶相媲美的可设计材料，并且在此，我们已经基于相同的晶体工程原理设计了一种系统的方法，以特定且理想地制造给定系统的共晶和共晶。在两个分子系统和两个药物系统中，成功地利用了超分子生长过程中强同分子合成子比弱异分子合成子的倾向性，反之亦然。讨论了对共晶和共晶形成以及它们之间的结构相互关系的分子水平的理解，这对从基础和应用的观点都是重要的。另一方面，通过相图解决了建立低熔点组合物作为共晶或共晶的模糊性。

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