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Structure‐function relationships in the visual system in multiple sclerosis: an MEGMEG and OCTOCT study

机译：多发性硬化症视觉系统中的结构功能关系： meg meg 和 10月 10月 学习

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Abstract <section xml:id="acn3415-sec-0001"> <title type="main">Background > We conducted a multi‐modal optical coherence tomography ( <fc>OCT</fc> ) and magnetoencephalography ( <fc>MEG</fc> ) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity ( <fc>FC</fc> ) in the visual network influenced by optic neuritis ( <fc>ON</fc> ) in patients with multiple sclerosis ( <fc>MS</fc> ). </section> <section xml:id="acn3415-sec-0002"> <title type="main">Methods > One hundred and two <fc>MS</fc> patients were included in this <fc>MEG</fc> / <fc>OCT</fc> study. Retinal <fc>OCT</fc> data were collected from the optic discs, macular region, and segmented. Neuronal activity and <fc>FC</fc> in the visual cortex was estimated from source‐reconstructed resting‐state <fc>MEG</fc> data by computing relative power and the phase lag index ( <fc>PLI</fc> ). Generalized estimating equations ( <fc>GEE</fc> ) were used to account for intereye within‐patient dependencies. </section> <section xml:id="acn3415-sec-0003"> <title type="main">Results > There was a significant relationship for both relative power and <fc>FC</fc> in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of <fc>MSON</fc> , particularly for connectivity in the alpha bands and the outer macular layers. In the absence of <fc>MSON</fc> , this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers. </section> <section xml:id="acn3415-sec-0004"> <title type="main">Conclusion > These results suggest that visual cortex <fc>FC</fc> more than activity alters in the presence of <fc>MSON</fc> , which may guide the understanding of <fc>FC</fc> plasticity effects following <fc>MSON</fc> . </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“acn3415-abs-0001”> <标题类型=“main”>抽象</ title> <第XML：ID =“ACN3415-SEC-0001”> <title type =“main”>背景</ title> > 我们进行了多模态光学相干断层扫描（ <FC> OCT </ FC> ）和磁性脑图（ <FC> MEG </ FC> ）测试测试视网膜层完整性和电生理活动和连接之间是否存在关系（ <FC> FC </ FC> ）在视觉网络受到视神经炎的影响（ <fc>在</ fc>上 ）患有多发性硬化症的患者（ <FC> MS </ FC> ）。 </ p> </部分> <第XML：ID =“ACN3415-SEC-0002”> <标题类型=“main”>方法</ title> > 一百零二 <FC> MS </ FC> 患者被包含在内 <FC> MEG </ FC> / <FC> OCT </ FC> 学习。视网膜 <FC> OCT </ FC> 从光盘，黄斑区域和分段收集数据。神经元活动和 <FC> FC </ FC> 在Visual Cortex中估计来自源重建的休息状态 <FC> MEG </ FC> 通过计算相对功率和阶段滞后指数的数据（ <FC> PLI </ FC> ）。广义估计方程（ <FC> GEE </ FC> ）用于考虑患者内部依赖的侵略性。 </ p> </部分> <第XML：ID =“ACN3415-SEC-0003”> <标题类型=“main”>结果</ title> > 对相对权力和相对权力有很大的关系 <FC> FC </ FC> 在视网膜厚度的视觉皮层中。这些发现受到了存在的影响 <FC> MSON </ FC> 那 特别是</ i> 用于alpha带和外部黄斑层中的连接。在缺少...之下 <FC> MSON </ FC> ，这种关系由下频带（THETA，DELTA）和内和外视网膜层主导。 </ p> </部分> <第XML：ID =“ACN3415-SEC-0004”> <标题类型=“main”>结论</ title> > 这些结果表明视觉皮质 <FC> FC </ FC> 在存在的情况下，不仅仅是活动改变 <FC> MSON </ FC> ，这可能引导理解 <FC> FC </ FC> 可塑性效应后面 <FC> MSON </ FC> 。 </ p> </部分> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-18063/'>《Advanced materials interfaces》</a> <b style="margin: 0 2px;">|</b><span>2017年第9期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tewarie Prejaas&option=202" target="_blank" rel="nofollow">Tewarie Prejaas;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Balk Lisanne J.&option=202" target="_blank" rel="nofollow">Balk Lisanne J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hillebrand Arjan&option=202" target="_blank" rel="nofollow">Hillebrand Arjan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Steenwijk Martijn D.&option=202" target="_blank" rel="nofollow">Steenwijk Martijn D.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Uitdehaag Bernard M. J.&option=202" target="_blank" rel="nofollow">Uitdehaag Bernard M. J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stam Cornelis J.&option=202" target="_blank" rel="nofollow">Stam Cornelis J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Petzold Axel&option=202" target="_blank" rel="nofollow">Petzold Axel;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of NeurologyNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of NeurologyNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of Clinical Neurophysiology and MEG CenterNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of NeurologyNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of NeurologyNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of Clinical Neurophysiology and MEG CenterNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> <p>Department of NeurologyNeuroscience Campus AmsterdamAmsterdam Netherlands;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Functional connectivity&option=203" rel="nofollow">Functional connectivity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=magnetoencephalography&option=203" rel="nofollow">magnetoencephalography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multiple sclerosis&option=203" rel="nofollow">multiple sclerosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neuronal oscillations&option=203" rel="nofollow">neuronal oscillations;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=optical coherence tomography&option=203" rel="nofollow">optical coherence tomography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=visual cortex&option=203" rel="nofollow">visual cortex;</a> </p> <div class="translation"> 机译：功能连通性;磁性脑图;多发性硬化;神经元振荡;光学相干断层扫描;视觉皮质; 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