Multicomponent Adducts of Pyridoxine: An Evaluation of the Formation of Eutectics and Molecular Salts

Ganduri Ramesh; Cherukuvada Suryanarayan; Row Tayur N. Guru

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Multicomponent Adducts of Pyridoxine: An Evaluation of the Formation of Eutectics and Molecular Salts

机译：吡rid醇的多组分加合物：共晶和分子盐形成的评价

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Cocrystallization of pyridoxine (vitamin B6) with several biologically important molecules was undertaken with the intent of successfully designing various hydrogen bonded adducts such as salts, cocrystals, and eutectics. Pyridoxine formed eutectics with isoniazid (an antitubercular drug) and nicotinic acid (vitamin B3) and molecular salts with para-aminobenzoic acid (a bioactive) and saccharin (an artificial sweetener), respectively, in accordance to our design strategy. A salt cocrystal, a precisely conjugate acid-base cocrystal, was obtained for the pyridoxine-para-nitrobenzoic acid combination. The role of supramolecular affinity of hydrogen bonding functional groups and Delta pK(a) differences leading to the formation of above diverse adducts was discussed. This study underpins the need for full-fledged supramolecular compatibility studies of multivitamin/drug combinations toward the development of optimal and/or synergistic combination formulations.

机译：吡ido醇（维生素B6）与几种生物学上重要的分子进行了共结晶，目的是成功设计出各种氢键加成物，例如盐，共晶体和低共熔物。根据我们的设计策略，吡rid醇分别与异烟肼（一种抗结核药）和烟酸（维生素B3）形成共晶，并与对氨基苯甲酸（一种生物活性物质）和糖精（一种人造甜味剂）形成分子盐。对于吡ido醇-对硝基苯甲酸组合，获得了盐共晶体，即精确的共轭酸-碱共晶体。讨论了氢键官能团的超分子亲和力和Delta pK（a）差异导致上述各种加合物形成的作用。这项研究强调了对多种维生素/药物组合进行全面的超分子相容性研究的需求，以开发最佳和/或协同组合制剂。

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《Crystal growth & design》 |2015年第7期|共7页
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Ganduri Ramesh; Cherukuvada Suryanarayan; Row Tayur N. Guru;
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1. Multicomponent Adducts of Pyridoxine: An Evaluation of the Formation of Eutectics and Molecular Salts [J] . Ganduri Ramesh, Cherukuvada Suryanarayan, Row Tayur N. Guru Crystal growth & design . 2015,第7期

机译：吡rid醇的多组分加合物：共晶和分子盐形成的评价
2. Sodium-salt adduct fullerenes prevent self-association and amyloid β fibril formation: molecular dynamics approach [J] . Balderas Altamirano Miguel Angel, Basurto-Islas Gustavo, Martinez-Herrera Melchor, Soft Materials . 2020,第1a4期

机译：钠盐加合物富勒烯防止自我关联和淀粉样蛋白β原纤维形成：分子动力学方法
3. Selective molecular recognition of arginine by anionic salt bridge formation with bis-phosphate crown ethers: Implications for gas phase peptide acidity from adduct dissociation [J] . Julian RR, Beauchamp JL Journal of the American Society for Mass Spectrometry . 2004,第4期

机译：通过双磷酸盐冠醚与阴离子盐桥形成的精氨酸的选择性分子识别：加合物离解对气相肽酸度的影响
4. Electrochemically-Induced Migration of Fullerene Adducts: Formation of Bis-Adducts from Mono-Adducts in THF [C] . Luis Echegoyen, Marcel Beulen, Nazario Martin The Meeting of the Electrochemical Society . 2001

机译：富勒烯加合物的电化学诱导的迁移：在THF中的单余处形成双加合物
5. Adduct conformational polymorphism explains adduct mutational complexity based on studies of the major adduct of benzo(a)pyrene in a mutational hotspot. [D] . Jelinsky, Scott A. 1997

机译：加合物构象多态性基于突变热点中苯并（a）py的主要加合物的研究，解释了加合物突变的复杂性。
6. Hexadecyl-Containing Organic Salts as Novel Organogelatorsfor Ionic Eutectic and Molecular Liquids [O] . CesarN. Prieto Kullmer, Daniel Ta, Christian Y. Chen, 2019

机译：含十六烷基有机盐的新型有机胶凝剂用于离子液体共晶液体和分子液体
7. Selective molecular recognition of arginine by anionic salt bridge formation with bis-phosphate crown ethers: implications for gas phase peptide acidity from adduct dissociation [O] . Julian Ryan R, Beauchamp J.L 2004

机译：通过双磷酸盐冠醚与阴离子盐桥形成的精氨酸的选择性分子识别：加合物解离对气相肽酸度的影响
8. Evaluation of the Health Aspects of Pyridoxine and Pyridoxine Hydrochloride as Food Ingredients. [R] . 1978

机译：作为食品配料的吡哆醇和盐酸吡哆醇的健康方面的评价。

Multicomponent Adducts of Pyridoxine: An Evaluation of the Formation of Eutectics and Molecular Salts

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