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首页> 外文期刊>Advances in Animal Biosciences >A parsimonious model for an analysis of parent-of-origin effects on beef traits in dual-purpose Simmental
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A parsimonious model for an analysis of parent-of-origin effects on beef traits in dual-purpose Simmental

机译：分析双目的模拟中牛肉特征的分析的解析模型

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摘要

Genomic imprinting is a term applied to an epigenetic phenomenon where alleles are fully or partially inactivated depending on their parental origin. The relevance of this kind ofparent-of-origin effects (POEs) for agriculturally important traits is widely known. A model (imprinting model) with a transmitting ability (TA) as sire and a TA as dam has been proposed that provides an estimate of the imprinting variance, whether the allelic inactivation is maternal, paternal, full or partial. Although themodel can be used in a reduced version, large data sets still prevent the imprinting variance from being estimated. To further reduce the size of the equation system, we developed a parsimonious imprinting model with genetic effects for male ancestors only, as the TA as dam is replaced by her father's TA. This parsimonious model was applied to 1366160 Simmental fattening bulls with slaughter data available on killing out percentage, net BW gain, EUROP class and fat score in a linear and generalised linear version. The pedigrees contained up to 2 637 761 ancestors. Proportion of the total genetic variance attributed to POEs ranged between 8.6% and 17.0%%. On average, the maternal gamete accounted for the greater proportion of the imprinting variance. An equivalent version of the parsimonious model facilitated the estimation of POEs with reliabilities ranging between zero and 0.97.
机译：基因组印记是应用于表观遗传现象的术语，其中取决于其父母来源完全或部分地灭活等位基因。这种原始术语的相关性（Poes）在农业上重要的特征是众所周知的。已经提出了一种模型（印迹模型）与发射能力（TA）作为岩石和TA作为大坝，其提供了对印记差异的估计，是等位基因失活是否是母体，父，满或部分。虽然可以在减少版本中使用主题，但大数据集仍然防止估计压印方差。为了进一步降低方程式系统的大小，我们开发了一种具有对男性祖先的遗传效果的报价印迹模型，因为大坝被父亲的TA所取代。这种帕克思般的模型应用于1366160个Simmental肥胖公牛，屠宰数据可用于杀灭百分比，净BW增益，欧式级和线性线性版本中的脂肪得分。这些章节包含最多2 637 761个祖先。归因于POES的总遗传方差的比例范围为8.6％和17.0 %%。平均而言，母亲配子占印记差异的比例较大。同样版本的解析模型促进了可靠性范围之间的POES估计，范围为零0.97。

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  • 来源
    《Advances in Animal Biosciences》 |2017年第1期|共1页
  • 作者

    I. Blunk; M. Mayer; H. Hamann; N. Reinsch;

  • 作者单位

    Institut fur Genetik und Biometrie Leibniz-Institut fur Nutztierbiologie (FBN) Wilhelm-Stahl-Allee 2 18196 Dummerstorf Germany;

    Institut fur Genetik und Biometrie Leibniz-Institut fur Nutztierbiologie (FBN) Wilhelm-Stahl-Allee 2 18196 Dummerstorf Germany;

    Landesamt fur Geoinformation und Landentwicklung Baden-Wurttemberg Dienststelle Kornwestheim Stuttgarter Strasse 161 70806 Kornwestheim Germany;

    Institut fur Genetik und Biometrie Leibniz-Institut fur Nutztierbiologie (FBN) Wilhelm-Stahl-Allee 2 18196 Dummerstorf Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物学;
  • 关键词

    carcass trait; epigenetics; genomic imprinting; parent-of-origin effect; Simmental;

    机译：胴体性状;表观学;基因组印记;父母起源效果;SIMMENTAL;

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