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首页> 外文期刊>ACS Sustainable Chemistry & Engineering >Novel Biocatalyst for Efficient Synthesis of Catecholic Products
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Novel Biocatalyst for Efficient Synthesis of Catecholic Products

机译：新型生物催化剂，用于高效合成儿茶醇产品

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摘要

Catecholic compounds have found broad applications in various fields such as foods, cosmetics, and pharmaceuticals due to their huge pharmacological effects and promising health benefits. In this work, tyrosinase-Cu-3(PO4)(2) hybrid composites (TCHCs) were employed as a new biocatalyst for regioselective ortho-hydroxylation reactions to produce two typical catecholic products, L-3,4-dihydroxyphenylalanine (L-DOPA) and piceatannol, with excellent productivities obtained (254 mg/L/h and 1.9 g/L/h, respectively) that are the highest among the data reported in literature. This new biocatalyst offers advantages such as greenness, easy and inexpensive preparation, and excellent catalytic activity and stability. The recyclability and storage stability of TCHCs can be significantly enhanced by encapsulation into copper alginate gels. The developed TCHC-alginate beads maintained their original activity for over 1 month and over 10 days when stored at 30 and 60 degrees C, respectively, and retained 78.6% of the original activity after reaction for 10 cycles.
机译：由于其巨大的药理学效应和有前途的健康益处，所以在各种领域中发现了在各种领域的广泛应用具有广泛的应用。在这项工作中，酪氨酸酶-Cu-3（PO4）（2）杂化复合材料（TCHC）作为用于区域选择性邻羟基化反应的新生物催化剂，以产生两种典型的传播产物，L-3,4-二羟基苯丙氨酸（L-DOPA ）和Piceatannol，获得了优异的产品（分别为254 mg / L / h和1.9克/升/小时），其在文献中报告的数据中最高。这种新的生物催化剂提供了绿色，容易且廉价的制备等优点，以及出色的催化活性和稳定性。通过封装成铜藻酸盐凝胶，可以显着提高TCHC的可回收性和储存稳定性。研制的Tchc-海藻酸盐珠粒在30℃和60摄氏度的储存时保持原始活性超过1个月，超过10天，并在反应10次循环后保留78.6％的原始活性。

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