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首页> 外文期刊>ACS Sustainable Chemistry & Engineering >Reduction and Protection: One-Step Synthesis of Polydopamine- Coated Silver Nanowires with Superior Biosafety for Cancer Treatment
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Reduction and Protection: One-Step Synthesis of Polydopamine- Coated Silver Nanowires with Superior Biosafety for Cancer Treatment

机译:减少和保护:多莨菪碱涂覆银纳米线的一步合成具有癌症治疗的优越生物安全性

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摘要

Rigorous synthetic methods and potential biotoxicity limit the clinical transformation of metal-based nanomaterials (MNs). Herein, we proposed a novel onestep synthetic approach for silver nanowires (AgNWs) and improved their biosafety tremendously. Dopamine (DA) functioned as a reductant for AgNW formulation in the alkaline condition instantaneously and a protective agent by polymerizing to polydopamine (PDA) on the surface of AgNWs to form AgNWs@PDA. The protection of PDA on the AgNWs in situ enhanced the biosafety and photothermal conversion of AgNWs, which suggested potential for photothermal therapy in vivo. The results revealed that the AgNWs@PDA showed superior biosafety and antitumor efficacy than AgNWs. Overall, this work presents a new one-step synthetic approach for enhancing the biosafety of toxic MNs universally without weakening their surface plasmon resonance effect, which facilitates further clinical transformation.
机译:严格的合成方法和潜在的生物毒性限制金属基纳米材料(MNS)的临床转化。 在此,我们提出了一种用于银纳米线(AGNW)的新的诺斯特步合法,并巨大地改善了它们的生物安全。 多巴胺(DA)用作瞬时用作碱性条件的AgNW制剂的还原剂和通过在AgNW的表面上聚合到聚德莫胺(PDA)中的保护剂以形成AgNWS @ PDA。 PDA对agnws的原位保护增强了Agnws的生物安全和光热转化,这提出了体内光热疗法的潜力。 结果表明,Agnws @ PDA显示出优异的生物安全和抗肿瘤效果而不是Agnws。 总体而言,这项工作介绍了一种新的一步综合方法,用于普遍普遍地增强毒性MNS的生物安全性,而不会削弱其表面等离子体共振效应,这有利于进一步的临床转化。

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