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首页> 外文期刊>ACS Sustainable Chemistry & Engineering >Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery
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Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery

机译：基于稳定和生物相容性的纤维素的CaCO3微球，可调谐pH响应药物递送

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摘要

Controlling the structure, particularly the structure template stability, has great potential for the fabrication of high-capacity and renewable drug carriers. Herein, novel porous CaCO3 microspheres about 2-3.5 μm with hollow cellulose nanoparticles (NPs, diameter centered at 15-35 nm) as templates were first assembled, with a highly specific surface area of ~363 m~2/g. The hollow cellulose NPs were previously prepared by the water-soluble dialdehyde cellulose, followed by the reduction of L-arginine (RDACws). Such self-assembled CaCO3 microspheres showed outstanding stability, which could retain high porosity for over 4 weeks under ethanol storage conditions, due to the electrostatic interactions between Ca~(2+) and the preassembled RDACws nanostructures. Furthermore, the porous CaCO3 microspheres as potential drug carriers showed good encapsulation efficiency, excellent pH responsiveness (pH = 2.0 7.4), and good biocompatibility, which could control the drug release at a specific location. The CaCO3 microspheres regulated by sustainable hollow cellulose NPs put forward for the first time a sustained drug release, demonstrating that the cellulose hollow NPs together with the mineralization theory bring a brilliant prospect to biomineral materials.
机译：控制结构，特别是结构模板稳定性，具有巨大的制造高容量和可再生药物载体的潜力。在此，具有作为模板的中空纤维素纳米颗粒（NPS，直径为中心）的新型多孔CaCO 3微球，其作为模板，具有〜363m〜2 / g的高度比表面积。中空纤维素NPS先前通过水溶性二醛纤维素制备，然后减少L-精氨酸（RDACW）。这种自组装的CaCO 3微球显示出突出的稳定性，其由于Ca〜（2+）和预制的Rdacws纳米结构之间的静电相互作用，可以在乙醇储存条件下保持高孔隙率超过4周。此外，作为潜在药物载体的多孔CaCO 3微球显示出良好的包封效率，优异的pH反应性（pH = 2.0 7.4），以及良好的生物相容性，可以控制特定位置的药物释放。通过可持续的中空纤维素NPS调节的CaCO3微球，首次提出持续的药物释放，证明纤维素中空NP与矿化理论一起带来了辉煌的前景。

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  • 作者

    Guihua Yan; Yunchao Feng; Zhebang Gao;

  • 作者单位

    College of Energy Fujian Engineering and Research Center of Clean and High-valued Technologies for Biomass Xiamen Key Laboratory of Clean and High-valued Applications of Biomass Xiamen University Xiang'an South Road Xiamen 361102 P. R. China;

    College of Energy Fujian Engineering and Research Center of Clean and High-valued Technologies for Biomass Xiamen Key Laboratory of Clean and High-valued Applications of Biomass Xiamen University Xiang'an South Road Xiamen 361102 P. R. China;

    College of Energy Fujian Engineering and Research Center of Clean and High-valued Technologies for Biomass Xiamen Key Laboratory of Clean and High-valued Applications of Biomass Xiamen University Xiang'an South Road Xiamen 361102 P. R. China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学工业;
  • 关键词

    cellulose; biomaterial; stability; biocompatibility; pH-responsive;

    机译：纤维素;生物材料;稳定性;生物相容性;pH响应;

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