Turning Liquid Propofol into Solid (without Freezing It): Thermodynamic Characterization of Pharmaceutical Cocrystals Built with a Liquid Drug

Bacchi Alessia; Capucci Davide; Giannetto Marco; Mattarozzi Monica; Pelagatti Paolo; Rodriguez-Hornedo Nair; Rubin Katia; Sala Andrea

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Turning Liquid Propofol into Solid (without Freezing It): Thermodynamic Characterization of Pharmaceutical Cocrystals Built with a Liquid Drug

机译：将液体丙泊酚变成固体（不冻结）：用液体药物构建的药物共晶体的热力学表征

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Most drugs are delivered as crystalline solids, but some widely used pharmaceutical ingredients cannot be crystallized at ambient conditions: propofol, one of the most widely used anesthetic agents in the world is a liquid. Here we stabilize propofol in a crystalline phase by cocrystallization, and we thoroughly characterize the structural and thermodynamic properties of the new materials. Ternary solubility diagrams of a liquid pharmaceutical ingredient cocrystallized with a solid coformer are presented and analyzed for the first time. It is shown that, when equilibrated with the solid cocrsytal, the concentration of propofol in water is kept constant in a wide range of starting compositions.

机译：大多数药物以结晶固体形式提供，但某些广泛使用的药物成分无法在环境条件下结晶：异丙酚是世界上使用最广泛的麻醉剂之一。在这里，我们通过共结晶将丙泊酚稳定在结晶相中，并彻底表征了新材料的结构和热力学性质。首次显示并分析了与固体共形成剂共结晶的液体药物成分的三元溶解度图。结果表明，当与固态苯甲醛平衡时，水中丙泊酚的浓度在各种起始组合物中均保持恒定。

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《Crystal growth & design》 |2016年第11期|共9页
作者
Bacchi Alessia; Capucci Davide; Giannetto Marco; Mattarozzi Monica; Pelagatti Paolo; Rodriguez-Hornedo Nair; Rubin Katia; Sala Andrea;
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正文语种 eng
中图分类晶体学;
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1. Turning Liquid Propofol into Solid (without Freezing It): Thermodynamic Characterization of Pharmaceutical Cocrystals Built with a Liquid Drug [J] . Bacchi Alessia, Capucci Davide, Giannetto Marco, Crystal growth & design . 2016,第11期

机译：将液体丙泊酚变成固体（不冻结）：用液体药物构建的药物共晶体的热力学表征
2. Solid-phase extraction combined with dispersive liquid-liquid microextraction/HPLC-UV as a sensitive and efficient method for extraction, pre-concentration and simultaneous determination of antiretroviral drugs nevirapine, efavirenz and nelfinavir in pharmaceutical formulations and biological samples [J] . Safari Mehregan, Shamsipur Mojtaba, Zohrabi Parvin, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2019,第期

机译：固相萃取结合分散液 - 液体微萃取/ HPLC-UV作为萃取，浓度和同时测定抗逆转录病毒药物Nevirapine，Efavirenz和Nelfinavir在药物制剂和生物样品中的敏感和有效的方法
3. Multi-residue determination of the sorption of illicit drugs and pharmaceuticals to wastewater suspended particulate matter using pressurised liquid extraction, solid phase extraction and liquid chromatography coupled with tandem mass spectrometry [J] . Baker D.R., Kasprzyk-Hordern B. Journal of chromatography, A: Including electrophoresis and other separation methods . 2011,第44期

机译：加压液相萃取，固相萃取和液相色谱-串联质谱联用用于残留药物对废水悬浮颗粒物的多残留测定
4. SUPERCRITICAL FLUIDS AS NEW MEDIA FOR THE GENERATION OF PHARMACEUTICAL COCRYSTALS - PHARMACEUTICAL CHARACTERIZATION OF THEOPHYLLINE-SACCHARIN COCRYSTALS [C] . L. Padrela, M. A. Rodrigues, V. Andre, European Meeting on Supercritical Fluids . 2010

机译：超临界流体作为新媒体，用于产生药物酰基钴的药物特征 - 甲酰甲酰胺烯库的药物特征
5. Understanding the solution phase chemistry and solid state thermodynamic behavior of pharmaceutical cocrystals. [D] . Maheshwari, Chinmay. 2012

机译：了解药物共晶体的溶液相化学和固态热力学行为。
6. Tetrahydrothiophene‐Based Ionic Liquids: Synthesis and Thermodynamic Characterizations [O] . Dr. Alexa Schmitz, Mark Bülow, Dana Schmidt, 2021

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7. Thermodynamics as a Tool for the Optimization of Drug Binding, Thermodynamics - Interaction Studies - Solids, Liquids and Gases [O] . Matesanz Ruth, Pera Benet, Díaz José Fernando 2011

机译：热力学作为优化药物结合的工具，热力学-相互作用研究-固体，液体和气体
8. Thermodynamic Behavior of Coal Liquids in the Presence of Coal Solids Characterization of IOM and Ash. Final Report, June 1-October 1, 1985 [R] . Holder, G. D., Dempsey, D. M. 1985

机译：煤体中存在的煤液热力学行为表征IOm和灰分。最终报告，1985年6月1日至10月1日

Turning Liquid Propofol into Solid (without Freezing It): Thermodynamic Characterization of Pharmaceutical Cocrystals Built with a Liquid Drug

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