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首页> 外文期刊>Crystal growth & design >Toward novel pseudo-polymorphs of nifedipine: Elucidation of a slow crystallization process
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Toward novel pseudo-polymorphs of nifedipine: Elucidation of a slow crystallization process

机译：硝苯地平的新型假多晶型物：缓慢结晶过程的阐明

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The crystallization of nifedipine was studied by means of synchrotron-X-ray diffraction, single-crystal X-ray structural analysis, and Raman spectroscopy. The results of slow evaporation (24 h in minimum) using dimethyl sulfoxide (DMSO) are presented. Since fast crystallization processes (typically minutes) in different solvents always led to the final formation of the thermodynamically most stable a-polymorph of nifedipine, we observed a novel pseudo-polymorph due to slow crystallization from DMSO. The single-crystal X-ray structure of the solvated species nifedipine-DMSO (1:1) is reported for the first time. In addition, the crystallization process on surfaces was followed by means of light microscopy and environmental scanning electron microscopy (ESEM) coupled with energy-dispersive X-ray spectroscopy (EDS) analysis. Different diffractions pattern and Raman spectra were observed for crystals grown from stock solution and those obtained by drying the solution on soda lime silicate surfaces.
机译：通过同步加速器X射线衍射，单晶X射线结构分析和拉曼光谱研究了硝苯地平的结晶。给出了使用二甲亚砜（DMSO）进行缓慢蒸发（最少24小时）的结果。由于在不同溶剂中的快速结晶过程（通常为数分钟）始终会导致最终形成硝苯地平的热力学最稳定的α-多晶型物，因此，由于从DMSO中缓慢结晶，我们观察到了一种新型的假多晶型物。首次报道了溶剂化的硝苯地平-DMSO（1：1）的单晶X射线结构。此外，通过光学显微镜和环境扫描电子显微镜（ESEM）结合能量色散X射线光谱（EDS）分析来跟踪表面的结晶过程。从储备溶液中生长的晶体和通过在钠钙硅酸盐表面上干燥溶液获得的晶体观察到不同的衍射图和拉曼光谱。

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