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Sex hormones in alcohol consumption: a systematic review of evidence

机译：酒精消费中的性激素：对证据的系统审查

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摘要

Sex hormones play an important role in establishing sex-distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Here, we systematically reviewed articles that studied sex hormone impacts on alcohol consumption and alcohol use disorder (AUD). An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre-specified criteria for relevance and quality assurance. A total of 50 articles, including 19 human studies and 31 animal studies, were selected for this review. Existing evidence supports the association of increased testosterone level and increased risk for alcohol use and AUD in males but results are inconclusive in females. In contrast, the evidence supports the association of increased estrogen level and increased alcohol use in females, with mixed findings reported in males. Much less is known about the impact of progestins on alcohol use and misuse in human subjects. Future observational and experimental studies conducted in both sexes with a comprehensive hormone panel are needed to elucidate the impact of the interplay between various sex hormone levels during various developmental stages on alcohol use-related phenotypes and AUD.
机译：性激素在建立性独特的脑结构和功能变异方面发挥着重要作用，这可能导致酒精消费行为的性别差异。在这里，我们系统地审查了研究性激素对酒精消费和酒精使用障碍（AUD）影响的物品。在Medline，PubMed，Scopus和Cinahl数据库中进行了广泛的文献搜索，确定了776篇文章，然后评估了预先指定的相关性标准，以获得相关性和质量保证。选择了50篇文章，其中包括19例人类研究和31种动物研究，为这次审查。现有证据支持睾酮水平增加的关联，并增加酒精使用风险和男性患者，但结果是雌性的不确定。相比之下，证据支持雌激素水平增加的关联，并增加了女性的酒精用途，并在雄性中报告了混合结果。关于孕激素对酒精使用和滥用滥用的影响更大。需要在两性中进行的未来观测和实验研究，以综合激素小组进行，阐明在各种发育阶段对酒精使用相关表型和澳元的各种发育阶段之间的相互作用的影响。

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