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首页> 外文期刊>Addiction biology >Functional effects of synthetic cannabinoids versus Δ 9 9 ‐THC in mice on body temperature, nociceptive threshold, anxiety, cognition, locomotor/exploratory parameters and depression
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Functional effects of synthetic cannabinoids versus Δ 9 9 ‐THC in mice on body temperature, nociceptive threshold, anxiety, cognition, locomotor/exploratory parameters and depression

机译：合成大麻素对体温，伤害阈值，焦虑，认知，运动/探索参数和抑郁症小鼠δ99 -THC的功能效果

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Abstract Synthetic cannabinoids are psychoactive substances designed to mimic the euphorigenic effects of the natural cannabis. Novel unregulated compounds appear once older compounds become illegal. It has been previously reported that synthetic cannabinoids are different than Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) as they have chemical structures unrelated to Δ 9 ‐THC, different metabolism and, often, greater toxicity. This study aimed to investigate the effects of three novel synthetic cannabinoids and pure Δ 9 ‐THC on body temperature, nociceptive threshold, anxiety, memory function, locomotor and exploratory parameters, and depression. We performed a battery of behavioural and motor tests starting 50?minutes post i.p. injection of each drug to adult ICR mice. The synthetic cannabinoids that were used are AB‐FUBINACA, AB‐CHMINACA and PB‐22. All synthetic cannabinoids and Δ 9 ‐THC caused hypothermia, but only Δ 9 ‐THC induced a clear antinociceptive effect. All synthetic cannabinoids and Δ 9 ‐THC caused decreased anxiety levels, spatial memory deficits and decreased exploratory behaviour as measured in the elevated plus maze, Y‐maze and staircase paradigm, respectively. However, all synthetic cannabinoids but not Δ 9 ‐THC demonstrated decreased locomotor activity in the staircase test. Moreover, only AB‐FUBINACA and Δ 9 ‐THC affected the gait balance and grip strength of the mice as was assessed by the latency time to fall from a rod. In the forced swimming test, PB‐22 caused elevated depression‐like behaviour while AB‐FUBINACA induced a reversed effect. These results suggest varied effects among different synthetic cannabinoids and Δ 9 ‐THC. Further studies are needed to characterize the overall effects and differences between these synthetic cannabinoids and Δ 9 ‐THC.
机译：摘要合成大麻素是精神活性物质，旨在模仿自然大麻的兴奋作用。一旦老年人变得非法，就会出现新的未调节化合物。先前已经报道，合成大麻素不同于δ9-四氢呋喃（δ9-β），因为它们具有与δ9-βC，不同的代谢和通常更大的毒性无关的化学结构。本研究旨在探讨三种新型合成大麻素和纯δ9 - 纯度对体温，伤害阈值，焦虑，记忆功能，运动和探索参数的影响和抑郁症。我们执行了50分钟后的行为和电机测试的电池。将每种药物注射成成人ICR小鼠。使用的合成大麻素是AB-FUBACA，AB-CHMINACA和PB-22。所有合成大麻素和δ9-β引起体温过低，但只有δ9-否诱导透明的抗血汗效果。所有合成大麻素和δ9 - 致焦虑水平降低，空间记忆缺陷和降低，分别在升高的Plus迷宫，Y型迷宫和楼梯范围中测量。然而，所有合成的大麻素，但不是δ9-β在楼梯试验中表现出降低的运动活性。此外，只有AB-FUBINACA和δ9-否影响小鼠的步态平衡和握力，因为通过延迟时间从杆落下来评估。在强制游泳测试中，PB-22引起了较高的抑郁症行为，而AB-Fubinaca诱导逆转效果。这些结果表明不同合成大麻素和δ9-β的不同效应。需要进一步的研究来表征这些合成大麻素和δ9-β之间的整体效果和差异。

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