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首页> 外文期刊>Addiction biology >Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study
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Rich club and reward network connectivity as endophenotypes for alcohol dependence: a diffusion tensor imaging study

机译：丰富的俱乐部和奖励网络连接作为酒精依赖的内心型：扩散张量成像研究

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We aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol use disorder (AUD) and unaffected siblings, relative to healthy comparison individuals. Diffusion-weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network-based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD Siblings Controls). We also found rank ordered differences (Control Sibling AUD) for both nodal clustering coefficient and nodal local efficiency in reward system nodes, particularly left caudate, right putamen and left hippocampus. Network-based statistic analyses showed that AUD group had significantly weaker connectivity than controls in the right hemisphere, mostly in the edges connecting putamen and hippocampus with other brain regions. Our results suggest that reward system network abnormalities, especially in subcortical structures, and impairments in rich-club organization might be related to the familial predisposition for AUD.
机译：我们旨在审查酒精使用障碍（AUD）和未受影响的兄弟姐妹患者的奖励系统节点的全脑白质连接和局部拓扑，相对于健康的比较个体。扩散加权磁共振成像扫描是从18名患者获得的18名患者，15例未受影响的兄弟姐妹和15名健康对照。使用基于网络的统计和Connectomic分析检查了结构网络。 Connectomic分析表明，标准化丰富的俱乐部组织（AUD＆兄弟姐妹＆控件）显示了一个显着的有序差异。我们还发现排序差异（Control＆兄弟姐妹），用于奖励系统节点中的节点聚类系数和节点本地效率，特别是留下尾部，右腐烂和左海马。基于网络的统计分析表明，AUD组的连通性显着较弱，而不是右半球的控制，主要是与其他脑区连接腐凝和海马的边缘。我们的结果表明，奖励系统网络异常，特别是在富裕俱乐部组织中的副标题结构和损伤可能与澳元的家庭倾向有关。

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