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首页> 外文期刊>Addiction biology >The monoamine stabilizer (?)‐OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats
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The monoamine stabilizer (?)‐OSU6162 prevents the alcohol deprivation effect and improves motor impulsive behavior in rats

机译：单胺稳定剂（α） - OSU6162可防止醇剥夺效果，提高大鼠的运动冲动行为

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Abstract Alcohol craving, in combination with impaired impulse control, often leads to relapse. The dopamine system mediates the rewarding properties of alcohol but is also involved in regulating impulsive behavior. The monoamine stabilizer (?)‐OSU6162 (OSU6162) has the ability to stabilize dopamine activity depending on the prevailing dopaminergic tone and may therefore normalize the dopaminergic transmission regulating both alcohol use disorder and impulsivity. We have recently showed that OSU6162 attenuates voluntary alcohol consumption, operant alcohol self‐administration, alcohol withdrawal symptoms and cue‐induced reinstatement of alcohol seeking in rats. Here, we evaluated OSU6162's effects on motor impulsivity in Wistar rats that had voluntarily consumed alcohol or water for 10?weeks. The five‐choice serial reaction time task was used to measure motor impulsivity, and a prolonged waiting period (changed from 5 to 7?seconds) was applied to induce premature responses. OSU6162‐testing was conducted twice a week (Tuesdays and Fridays), every other week with regular baseline training sessions in between. We also tested OSU6162's effects on the alcohol deprivation effect in long‐term alcohol drinking Wistar rats. The results showed that OSU6162 (30?mg/kg) pre‐treatment significantly improved motor impulsivity in the five‐choice serial reaction time task in both alcohol and alcohol‐na?ve rats. Moreover, OSU6162 (30?mg/kg) pre‐treatment prevented the alcohol deprivation effect, i.e. relapse‐like drinking behavior after a forced period of abstinence in long‐term drinking rats. In conclusion, our results provide further support for OSU6162 as a novel treatment for alcohol use disorder. The results further indicate that improvement of motor impulse control might be one mechanism behind OSU6162's ability to attenuate alcohol‐mediated behaviors.
机译：摘要酒精渴望，与受损的冲动控制相结合，往往导致复发。多巴胺系统介导酒精的有益性，但也参与调节冲动行为。单胺稳定剂（α） - OSU6162（OSU6162）具有根据主要的多巴胺能调节的多巴胺活性稳定多巴胺活性，因此可以使多巴胺能速率正常化调节酒精使用障碍和冲动。我们最近显示OSU6162衰减自愿酒精消费，手术饮酒，酒精戒断症状和提示诱导的大鼠饮食恢复。在此，我们评估了OSU6162对Wistar大鼠的对运动冲动的影响，该大鼠已经自愿消耗了10次饮酒或水10？周。使用五项选择串行反应时间任务来测量电机冲动，并且延长等待时间（从5到7秒变为7秒）以诱导过早反应。 OSU6162-Testing每周进行两次（周二和星期五），每隔一周与常规基线培训会面之间进行。我们还测试了OSU6162对长期酒精饮用Wistar大鼠的酒精剥夺作用的影响。结果表明，OSU6162（30×Mg / kg）预处理在醇和酒精 - αve大鼠中的五种选择连续反应时间任务中显着提高了运动冲动。此外，OSU6162（30×Mg / kg）预处理预防醇剥夺作用，即在长期饮酒大鼠禁欲期后复发样饮酒行为。总之，我们的结果为OSU6162提供了进一步支持，作为酒精使用障碍的新型治疗方法。结果进一步表明，电机脉冲控制的改善可能是OSU6162衰减酒精介导行为的能力之后的一种机制。

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