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首页> 外文期刊>Addiction biology >Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk
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Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk

机译：醇脱氢酶基因多态性Rs1789891与灰质脑体积，酒精消费，酒精渴望和复发风险

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摘要

Alcohol metabolizing enzymes, such as the alcohol dehydrogenases and the aldehyde dehydrogenases, regulate the levels of acetaldehyde in the blood and play an important role in the development and maintenance of alcohol addiction. Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene cluster and the risk of alcohol dependence. The current study investigated the effect of this single nucleotide polymorphism on alcohol consumption, craving for alcohol, relapse risk and brain gray matter volume. Alcohol-dependent patients (n = 74) and controls (n = 43) were screened, genotyped and underwent magnetic resonance imaging scanning, and relapse data were collected during 3 months following the experiment. Alcohol-dependent A allele carriers reported increased alcohol craving and higher alcohol consumption compared with the group of alcohol-dependent individuals homozygous for the C allele, which displayed craving values similar to the control group. Further, follow-up data indicated that A allele carriers relapsed earlier to heavy drinking compared with individuals with two C alleles. Analyses of gray matter volume indicated a significant genotype difference in the patient group: individuals with two C alleles had reduced gray matter volume in the left and right superior, middle and inferior temporal gyri. Findings of the current study further support the relevance of genetic variants in alcohol metabolizing enzymes to addictive behavior, brain tissue volume and relapse risk. Genotype-dependent differences in acetaldehyde formation, implicated by earlier studies, might be the biological substrate of the genotype differences.
机译：醇代谢酶，例如醇脱氢酶和醛脱氢酶，调节血液中的乙醛水平，并在酒精成瘾的开发和维持中发挥重要作用。最近的基因组系统搜索在酒精脱氢酶基因集群中的单个核苷酸多态性（RS1789891，风险等位基因：A，保护等位基因：C）和酒精依赖的风险之间发现的缔合。目前的研究研究了这种单一核苷酸多态性对酒精消耗的影响，渴望酒精，复发风险和脑灰质体积。抑制醇类患者（n = 74）和对照（n = 43）被筛选，基因分型和接受磁共振成像扫描，在实验后3个月内收集复发数据。醇依赖性的等位基因载体报告了醇渴望增加，与C类等位基因纯合的酒精依赖性个体组相比，饮酒量增加，展示了类似于对照组的渴望值。此外，随访数据表明，与具有两种C等位基因的个体相比，等位基因载体与重饮中的重复饮酒。灰质体积的分析表明患者组中的重大基因型差异：具有两种C等位基因的个体在左右上的上级，中间和较小的颞甘氨地中具有降低的灰质体积。目前研究的结果进一步支持遗传变异在醇代谢酶中的遗传变异与上瘾行为，脑组织体积和复发风险的相关性。通过早期研究涉及丙醛形成的基因型依赖性差异，可能是基因型差异的生物学基础。

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  • 来源
    《Addiction biology》 |2019年第1期|共11页
  • 作者

    Bach Patrick; Zois Evangelos; Vollstaedt-Klein Sabine; Kirsch Martina; Hoffmann Sabine; Jorde Anne; Frank Josef; Charlet Katrin; Treutlein Jens; Beck Anne; Heinz Andreas; Walter Henrik; Rietschel Marcella; Kiefer Falk;

  • 作者单位

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Genet Epidemiol Psychiat Mannheim;

    Charite Univ Med Berlin Dept Psychiat &

    Psychotherapy Berlin Germany;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Genet Epidemiol Psychiat Mannheim;

    Charite Univ Med Berlin Dept Psychiat &

    Psychotherapy Berlin Germany;

    Charite Univ Med Berlin Dept Psychiat &

    Psychotherapy Berlin Germany;

    Charite Univ Med Berlin Dept Psychiat &

    Psychotherapy Div Mind &

    Brain Res Berlin Germany;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Genet Epidemiol Psychiat Mannheim;

    Heidelberg Univ Med Fac Mannheim Cent Inst Mental Hlth Dept Addict Behav &

    Addict Med Sq J5 D;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    ADH gene polymorphism; alcoholism; gray matter volume; MRI; relapse; rs1789891;

    机译：ADH基因多态性;酗酒;灰质体积;MRI;复发;RS1789891;

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