• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Addiction biology >Comparing rewarding and reinforcing properties between ‘bath salt’ 3,4‐methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats
【24h】

Comparing rewarding and reinforcing properties between ‘bath salt’ 3,4‐methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats

机译：在大鼠超声声用超声发声对“沐浴盐”3,4-甲基二甲基吡甲蛋白酮（MDPV）和可卡因之间的奖励和增强性能进行比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Abuse of synthetic psychostimulants like synthetic cathinones has risen in recent years. 3,4‐Methylenedioxypyrovalerone (MDPV) is one such synthetic cathinone that demonstrates a mechanism of action similar to cocaine. Compared to cocaine, MDPV is more potent at blocking dopamine and norepinephrine reuptake and is readily self‐administered by rodents. The present study compared the rewarding and reinforcing properties of MDPV and cocaine using systemic injection dose‐response and self‐administration models. Fifty kilohertz ultrasonic vocalizations (USVs) were recorded as an index of positive affect throughout experiments. In Experiment 1, MDPV and cocaine dose‐dependently elicited 50‐kHz USVs upon systemic injection, but MDPV increased USVs at greater rates and with greater persistence relative to cocaine. In Experiment 2, latency to begin MDPV self‐administration was shorter than latency to begin cocaine self‐administration, and self‐administered MDPV elicited greater and more persistent rates of 50‐kHz USVs versus cocaine. MDPV‐elicited 50‐kHz USVs were sustained over the course of drug load‐up whereas cocaine‐elicited USVs waned following initial infusions. Notably, we observed a robust presence of context‐elicited 50‐kHz USVs from both MDPV and cocaine self‐administering rats. Collectively, these data suggest that MDPV has powerfully rewarding and reinforcing effects relative to cocaine at one‐tenth doses. Consistent with prior work, we additionally interpret these data in supporting that MDPV has significant abuse risk based on its potency and subjectively positive effects. Future studies will be needed to better refine therapeutic strategies targeted at reducing the rewarding effects of cathinone analogs in efforts to ultimately reduce abuse liability.
机译：摘要滥用合成的手机疗法，如合成阴茎近年来上升。 3,4-甲基二氧基吡罗ROVOLONE（MDPV）是一种这样的合成显性酮，证明了类似于可卡因的作用机制。与可卡因相比，MDPV在阻断多巴胺和去甲肾上腺素再摄取时更有效，并且通过啮齿动物容易地自我施用。本研究比较了使用全身注射剂量 - 反应和自我管理模型的MDPV和可卡因的奖励和增强性能。五十千赫斯超声波发声（USV）被记录为整个实验的积极影响的指标。在实验1中，MDPV和可卡因在全身注射时依赖于50 kHz USV，但MDPV以更大的速率增加USV，并且相对于可卡因更大的持久性。在实验2中，开始MDPV自我施用的潜水时间短于延迟，以开始可卡因自我给药，自我管理的MDPV引发了50-kHz USVs与可卡因的更大和更持久的速率。 MDPV引发的50 kHz USV在药物加载过程中持续，而可卡因引发USVS在初始输注之后遭受过衰退。值得注意的是，我们观察到来自MDPV和可卡因自我施用大鼠的环境引发的50 kHz USV的强大存在。这些数据集体表明，MDPV在十分之一剂量下具有激动地奖励和加强效果。与事先工作一致，我们还在支持这些数据时，支持MDPV基于其效力和主观积极影响具有显着的滥用风险。将来需要进行未来的研究，以更好地精确治疗策略，旨在减少Cathinone类似物在最终减少滥用责任的努力中的奖励作用。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号