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首页> 外文期刊>Addiction biology >Putamen functional connectivity during inhibitory control in smokers and non‐smokers
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Putamen functional connectivity during inhibitory control in smokers and non‐smokers

机译：在吸烟者和非吸烟者中抑制控制期间的腐败功能连通性

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Abstract The putamen has been shown to play a key role in inhibitory control and addiction, and consists of distinct subregions associated with distinct functions. The anterior putamen is thought to be specialized in goal‐directed control or response‐monitoring in connection with frontal regions, whereas the posterior part is specialized in habitual or automatic responding in connection with sensorimotor regions. The present study is the first to delineate functional networks of the anterior and posterior putamen in a Go–NoGo response inhibition task, and to examine differences between smokers ( n ?=?25) and non‐smokers ( n ?=?23) within these networks. Functional connectivity analyses were conducted on fMRI data from a Go–NoGo study, using the generalized form of psychophysiological interaction with anterior and posterior putamen seed regions. In the context of inhibition, the anterior putamen exhibited connectivity with the anterior cingulate cortex (ACC) and precuneus ( p FWE ??.05), which was in line with previous literature. Conversely, the posterior putamen showed connectivity with regions implicated in sensorimotor processing. When we compared smokers to non‐smokers, we did not observe the expected weaker connectivity between the anterior putamen and ACC during inhibition in smokers. Instead, our study revealed stronger inhibition‐related connectivity between the anterior putamen and right insula in smokers. This finding highlights the involvement of putamen – insula interactions in addiction and impulse control.
机译：摘要已显示腐库在抑制控制和成瘾中发挥关键作用，并且由与不同功能相关的不同的子区域组成。前熔点被认为是与前部区域有关的目标导向的控制或响应监测，而后部专门从事习惯性或自动响应与传感器区域有关。本研究是第一个在Go-Nogo反应抑制任务中描绘前后腐烂的功能网络，并检查吸烟者（N？= 25）和非吸烟者之间的差异（n？=？23）这些网络。使用与前后和后浮子种子区域的通用形式的心理生理学相互作用，在Go-Nogo研究中对FMRI数据进行了功能性连接分析。在抑制的背景下，前浮子与前铰接皮质（ACC）和前型燃烧（P FWEα.05）表现出与前刺的旋转性的连接，这与先前的文献一致。相反，后浮子显示与涉及在传感器处理中的区域的连接。当我们将吸烟者与非吸烟者进行比较时，我们在吸烟者中抑制期间，我们并没有观察到前腐Putamen和ACC之间的预期较弱的连通性。相反，我们的研究表明，在吸烟者中，前腐败和右侧Insula之间存在更强的抑制相关连通性。这一发现凸显了腐凝 - insula相互作用在成瘾和脉冲控制中的参与。

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