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首页> 外文期刊>Addiction biology >Acupuncture inhibition of methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR
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Acupuncture inhibition of methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR

机译：针刺抑制甲基苯丙胺诱导的行为，多巴胺释放和细胞核中的热疗：II族MGLUR的调解

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摘要

Methamphetamine (METH) increases metabolic neuronal activity in the mesolimbic dopamine (DA) system and mediates the reinforcing effect. To explore the underlying mechanism of acupuncture intervention in reducing METH-induced behaviors, we investigated the effect of acupuncture on locomotor activity, ultrasonic vocalizations, extracellular DA release in the nucleus accumbens (NAcs) using fast-scan cyclic voltammetry and alterations of brain temperature (an indicator of local brain metabolic activity) produced by METH administration. When acupuncture was applied to HT7, but not TE4, both locomotor activity and 50-kHz ultrasonic vocalizations were suppressed in METH-treated rats. Acupuncture at HT7 attenuated the enhancement of electrically stimulated DA release in the NAc of METH-treated rats. Systemic injection of METH produced a sustained increase in NAc temperature, which was reversed by the DA D1 receptor antagonist SCH 23390 or acupuncture at HT7. Acupuncture inhibition of METH-induced NAc temperature was prevented by pre-treatment with a group II metabotropic glutamate receptors (mGluR2/3) antagonist EGLU into the NAc or mimicked by injection of an mGluR2/3 agonist DCG-IV into the NAc. These results suggest that acupuncture reduces extracellular DA release and metabolic neuronal activity in the NAc through activation of mGluR2/3 and suppresses METH-induced affective states and locomotor behavior.
机译：甲基苯丙胺（甲基）增加了叶胺蛋白多巴胺（DA）系统中的代谢神经元活性，并介导增强效果。为了探讨针灸干预的潜在机制，以减少甲状腺诱导的行为，我们研究了针刺对机车活动，超声声发作，用快速扫描循环伏安法和脑温度的改变（甲基施用产生的局部脑代谢活性的指标。当针灸施加到HT7时，但不是TE4，在甲状腺处理的大鼠中抑制了运动活性和50-kHz超声波发作。 HT7的针灸减弱了在NAC的大鼠NAC中的电刺激DA释放的增强。全身注射甲基产生的NAC温度持续增加，其通过DA D1受体拮抗剂SCH 23390或HT7的针灸逆转。通过用II族代购谷氨酸受体（MgluR2 / 3）拮抗剂EGLU预处理通过将MGLUR2 / 3激动剂DCG-IV注射NAC进入NAC的NAC或模拟NaC中的甲基诱导的NAC温度的针灸抑制。这些结果表明，通过MGLUR2 / 3的活化，针灸通过激活抑制了NAC的细胞外DA释放和代谢神经元活性，抑制了甲状腺动力学和运动行为。

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