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首页> 外文期刊>Addiction biology >Adolescent impulsivity as a sex-dependent and subtype-dependent predictor of impulsivity, alcohol drinking and dopamine D-2 receptor expression in adult rats
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Adolescent impulsivity as a sex-dependent and subtype-dependent predictor of impulsivity, alcohol drinking and dopamine D-2 receptor expression in adult rats

机译：青少年冲动作为性别依赖性和亚型依赖于脉冲性，酒精饮用和多巴胺D-2受体表达的血液依赖性预测因子

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Impulsivity is a personality trait associated with a heightened risk for drug use and other psychiatric conditions. Because impulsivity-related disorders typically emerge during adolescence, there has been interest in exploring methods for identifying adolescents that will be at risk to develop substance use disorders in adulthood. Here, we used a rodent model to assess inhibitory control (impulsive action) and impulsive decision making (impulsive choice) during adolescence (43-50 days old) or adulthood (93-100 days old) and then examined the impact of development on these impulsivity traits by re-testing rats 50 days later. Impulsive action was not stable from adolescence to adulthood in male rats and was lowest in adult male rats, relative to adolescents and female rats. Impulsive choice was stable across development and unaffected by age or sex. Next, we examined the connection between our model of impulsivity and two measures relevant to substance abuse research: the initiation of voluntary alcohol drinking and dopamine D-2 receptor (D2R) expression in the prelimbic prefrontal cortex. Consumption of saccharin-sweetened ethanol during 30-minute sessions in adulthood was associated with adolescent, but not adult, impulsive action, particularly in male rats. Prelimbic D2R expression was reduced in individuals with high levels of impulsive choice, and this relationship appeared to be strongest among female rats. The results of this study demonstrate that impulsive choice, along with its connection to D2R expression, is relatively unchanged by the process of development. For impulsive action, however, individual levels of impulsivity during adolescence predict drinking in adulthood despite changes in the measure during development.
机译：冲动是一种与毒品使用和其他精神病风险有关的人格特征。因为在青春期期间，由于冲动相关的疾病通常出现，因此探讨了鉴定鉴定危险的青少年来探讨将有风险的患者在成年期开发物质使用障碍。在这里，我们使用啮齿动物模型来评估青春期（43-50天）或成年期（93-100天）的抑制控制（冲动的行动）和冲动决策（冲动的选择），然后检查了发展的影响50天后通过重新测试大鼠的冲动性状。脉冲作用从青春期到雄性大鼠的青春期不稳定，相对于青少年和雌性大鼠在成年雄性大鼠中最低。冲动的选择在发育中稳定，并且不受年龄或性别影响。接下来，我们检查了我们的冲动性模型与与药物滥用研究有关的两项措施之间的联系：在预先甲基前皮质中开始自愿酒精饮用和多巴胺D-2受体（D2R）的表达。在成年期30分钟的30分钟季节期间消耗糖精甜乙醇的消耗与青少年，但不是成人，脉冲作用，特别是在雄性大鼠中有关。在具有高水平冲动选择的个体中，预先将前列腺D2R表达降低，并且这种关系似乎是雌性大鼠中最强的。该研究的结果表明，脉冲选择以及其与D2R表达的连接，通过开发过程相对不变。然而，对于冲动的作用，尽管在发育过程中的测量变化，但在成年期间在成年期间饮用的个性冲动程度。

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