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首页> 外文期刊>Addiction biology >Ethanol consumption following mild traumatic brain injury is related to blood‐brain barrier permeability
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Ethanol consumption following mild traumatic brain injury is related to blood‐brain barrier permeability

机译：轻度创伤性脑损伤后的乙醇消耗与血脑屏障渗透性有关

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Abstract Several preclinical and clinical studies that deal with the neuropathological consequences of mild traumatic brain injury (mTBI) have focused on unraveling its effect on ethanol drinking behavior. Previous reports describe changes in ethanol consumption, both in animal models of mTBI as well as in patients, after concussive brain injury. However, the neurobiological mechanisms underlying this phenomenon are still poorly understood. In the present study, we used a unique model of mouse lines divergently selected for high (HA) or low (LA) swim stress‐induced analgesia to examine the effect of mTBI on ethanol drinking behavior. In comparison with LA mice, their HA counterparts exhibited increased blood‐brain barrier (BBB) permeability, lower basal alcohol preference, and lower level of stress‐induced ethanol intake. Here, we showed that mTBI attenuates voluntary ethanol intake in LA, but not in HA mice. Interestingly, BBB disruption after mannitol infusion also decreases the level of ethanol drinking behavior in this line. We conclude that in alcohol‐preferring LA mice, BBB disruption as a consequence of mTBI attenuates ethanol consumption. Our results suggest that the innate level of BBB integrity plays a pivotal role in regulation of ethanol consumption in mice showing differential endogenous opioid system activity.
机译：摘要若干临床和临床研究，涉及轻度创伤性脑损伤（MTBI）的神经病理后果（MTBI）的临床研究旨在揭示其对乙醇饮酒行为的影响。以前的报告描述了在MTBI的动物模型以及患者的血液损伤后，描述了乙醇消费的变化。然而，这种现象的神经生物学机制仍然很差。在本研究中，我们使用了一个独特的小鼠线模型，用于高（HA）或低（LA）游泳应激诱导的镇痛，以检查MTBI对乙醇饮用行为的影响。与La小鼠相比，它们的HA对应物表现出血脑屏障（BBB）渗透性增加，较低的基础醇偏好和较低水平的应激诱导的乙醇摄入量。在这里，我们展示MTBI衰减在洛杉矶的自愿乙醇摄入，但不在HA小鼠中。有趣的是，甘露醇输注后BBB破坏也降低了这条线中乙醇饮用行为的水平。我们得出结论，在酒精偏爱La小鼠中，由于MTBI衰减乙醇消费而导致BBB破坏。我们的研究结果表明，BBB完整性的先天水平在显示差异内源性阿片类药物系统活动的小鼠中的乙醇消耗中起着枢转作用。

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