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首页> 外文期刊>Crystal growth & design >Zwitterionic Cocrystals of Flavonoids and Proline: Solid-State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance
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Zwitterionic Cocrystals of Flavonoids and Proline: Solid-State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance

机译：类黄酮和脯氨酸的两性离子共晶体：固态表征，药物特性和药代动力学性能。

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摘要

We utilized the concepts of crystal engineering to acquire cocrystals of D/L-proline with a variety of flavonoids and further evaluated the impact on solubility and pharmacokinetic of flavonoids. We have synthesized and characterized six D/L-proline cocrystals with flavonoids and their single crystal structures were revealed. The powder dissolution profiles were determined and the pharmacokinetic properties for Kae-L-Pro were analyzed and compared with the corresponding physical mixture. D/L-Proline was found to be a suitable coformer for a variety of structural similar flavonoids. This study may offer an alternative approach for the development of these widely used flavonoids.
机译：我们利用晶体工程学的概念来获得D / L-脯氨酸与各种类黄酮的共晶体，并进一步评估了对类黄酮的溶解度和药代动力学的影响。我们已经合成和表征了具有类黄酮的六个D / L-脯氨酸共晶体，并揭示了它们的单晶结构。确定了粉末的溶出曲线，并分析了Kae-L-Pro的药代动力学特性，并与相应的物理混合物进行了比较。发现D / L-脯氨酸是多种结构相似的类黄酮的合适的共形成者。这项研究可能为开发这些广泛使用的类黄酮提供了另一种方法。

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