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首页> 外文期刊>Crystal growth & design >A Rare Case of Mesomorphic Behavior-Molecular Reorientation of Itraconazole Liquid Crystal Induced by a Hygrothermal Treatment
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A Rare Case of Mesomorphic Behavior-Molecular Reorientation of Itraconazole Liquid Crystal Induced by a Hygrothermal Treatment

机译：湿热处理诱导伊曲康唑液晶的同构行为-分子重取向的罕见情况

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摘要

Liquid crystals constitute a unique class of soft state of matter exhibiting the counterintuitive combination of fluidity and order in addition to the Unique feature of controllable molecular orientation. Herein, we introduce the use of moisture sorption approach to reversibly realign mesogen molecules within a liquid crystalline phase of itraconazole, assigned to as a nematic phase (ITR-N), obtained by spray drying. This unique, nematic-to-smectic switching behavior of ITR was achieved via moisture triggered activation of molecular mobility of ITR molecules below the material's glass transition temperature (T-g). This phenomenon was characterized using small and wide-angle X-ray diffraction, scanning electron microscopy, and thermal analysis. The smectic phase was found to be formed by a 1:1 mol/mol ITR/water complex, an example of rare thermotropic mesomorphism of a solvent complex, and the water presence was found to be necessary for the material to retain the smectic order. The ordered sample, in the smectic phase, possessed a greater T-g than ITR-N due to an increase in order and subsequent increase in rigidity. This behavior highlights the ability of ITR to accommodate stress conditions via molecular rearrangement and thus resist full crystallization, which rationalizes the importance of the liquid crystalline phase.
机译：液晶构成了独特的一类软物质，除了具有可控制的分子取向的独特功能外，还表现出流动性和有序性的反直觉结合。在本文中，我们介绍了使用水分吸收方法，将伊曲康唑液晶相中的介晶分子可逆地重新排列，该相通过喷雾干燥获得，被指定为向列相（ITR-N）。通过在材料的玻璃化转变温度（T-g）以下，潮气触发了ITR分子的分子迁移性激活，从而实现了ITR这种独特的向列-近原子转换行为。使用小角度和广角X射线衍射，扫描电子显微镜和热分析来表征这种现象。发现近晶相是由1：1 mol / mol ITR /水络合物形成的，这是溶剂络合物的罕见的热致介晶的例子，并且发现水的存在对于材料保持近晶顺序是必要的。在近晶相中，有序样品比ITR-N具有更大的T-g，这是由于顺序增加以及随后的刚度增加。此行为强调了ITR通过分子重排适应应力条件并因此抵抗完全结晶的能力，这合理化了液晶相的重要性。

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